A small molecule has been identified that can mitigate the progression of an inherited form of deafness in transgenic mice by stabilizing mutant clarin-1, an essential component of a multimolecular complex of the mechanotransduction apparatus of hair cells in the inner ear.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Alagraman, K. et al. Nat. Chem. Biol. 12, 444–451 (2016).
Pan, L. & Zhang, M. Physiology (Bethesda) 27, 25–42 (2012).
Blanco-Sánchez, B., Clement, A., Fierro, J. Jr ., Washbourne, P. & Westerfield, M. Dis. Model. Mech. 7, 547–559 (2014).
Geng, R. et al. J. Neurosci. 32, 9485–9498 (2012).
Gopal, S.R. et al. J. Neurosci. 35, 10188–10201 (2015).
Verpy, E. et al. Nat. Genet. 26, 51–55 (2000).
Tian, G. et al. J. Biol. Chem. 284, 18980–18993 (2009).
Hebert, D.N., Lamriben, L., Powers, E.T. & Kelly, J.W. Nat. Chem. Biol. 10, 902–910 (2014).
Powers, E.T., Morimoto, R.I., Dillin, A., Kelly, J.W. & Balch, W.E. Annu. Rev. Biochem. 78, 959–991 (2009).
Apaja, P.M. & Lukacs, G.L. Physiology (Bethesda) 29, 265–277 (2014).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Lukacs, G. Chaperoning for hearing loss. Nat Chem Biol 12, 388–389 (2016). https://doi.org/10.1038/nchembio.2091
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchembio.2091