Bacterial pathogen–secreted proteases may have a key role in inhibiting a potentially widespread host-pathogen interaction. Activity-based protein profiling enabled the identification of a major Vibrio cholerae serine protease that limits the ability of a host-derived intestinal lectin to bind to the bacterial pathogen in vivo.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Marina Corral Spence/Nature Publishing Group
References
Willems, L.I., Overkleeft, H.S. & van Kasteren, S.I. Bioconjug. Chem. 25, 1181–1191 (2014).
Hatzios, S.K. et al. Nat. Chem. Biol. 10.1038/nchembio.2025 (22 February 2016).
Mandlik, A. et al. Cell Host Microbe 10, 165–174 (2011).
Biteen, J.S. et al. ACS Nano 10, 6–37 (2016).
Sadler, N.C. & Wright, A.T. Curr. Opin. Chem. Biol. 24, 139–144 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Wright, A. A cholera surveillance system. Nat Chem Biol 12, 203–204 (2016). https://doi.org/10.1038/nchembio.2039
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchembio.2039
