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Phospholipids

A neuroinflammation emerging target

Nature Chemical Biology volume 11, pages 99–100 (2015)Cite this article

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Lysophosphatidylserines (lyso-PSs) are an emerging class of signaling lipids implicated in human inflammatory and autoimmune diseases. A newly discovered phosphatidylserine-specific lipase, ABHD16A, together with the recently described lyso-PS lipase ABHD12 shed light on the in vivo regulation of lyso-PS, providing a potential enzymatic target for modulating neuroinflammatory responses.

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Figure 1: Regulation of lyso-PS by the ABHD16A-ABHD12 network, a potential immunomodulatory target.

Kim Caesar/Nature Publishing Group

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  1. Hee-Yong Kim is in the National Institute on Alcohol Abuse and Alcoholism, the National Institutes of Health, Bethesda, Maryland, USA.,

    Hee-Yong Kim

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  1. Hee-Yong Kim
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Correspondence to Hee-Yong Kim.

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Kim, HY. A neuroinflammation emerging target. Nat Chem Biol 11, 99–100 (2015). https://doi.org/10.1038/nchembio.1740

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