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Neuronal differentiation

5-HT6R can do it alone

Nature Chemical Biology volume 10, pages 488–489 (2014)Cite this article

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A study in this issue reports the 5-HT6 receptor as a new cyclin-dependent kinase 5 (Cdk5) substrate and reveals its noncanonical pathway, which mediates neuronal differentiation in hippocampus and striatum by interacting with Cdk5 and Cdc42 in an agonist-independent manner.

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Figure 1: Constitutive interaction of 5-HT6R with Cdk5-p35 leads to receptor phosphorylation, which further recruits Cdc42 and promotes neurite outgrowth.

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References

  1. Nikolic, M., Dudek, H., Kwon, Y.T., Ramos, Y.F. & Tsai, L.H. Genes Dev. 10, 816–825 (1996).

    Article  CAS  Google Scholar 

  2. Duhr, F. et al. Nat. Chem. Biol. 10, 590–597 (2014).

    Article  CAS  Google Scholar 

  3. Monsma, F.J. Jr., Shen, Y., Ward, R.P., Hamblin, M.W. & Sibley, D.R. Mol. Pharmacol. 43, 320–327 (1993).

    CAS  PubMed  Google Scholar 

  4. Ruat, M. et al. Biochem. Biophys. Res. Commun. 193, 268–276 (1993).

    Article  CAS  Google Scholar 

  5. Cheung, Z.H., Chin, W.H., Chen, Y., Ng, Y.P. & Ip, N.Y. PLoS Biol. 5, e63 (2007).

    Article  Google Scholar 

  6. Millan, M.J. et al. Nat. Rev. Drug Discov. 11, 141–168 (2012).

    Article  CAS  Google Scholar 

  7. Meffre, J. et al. EMBO Mol. Med. 4, 1043–1056 (2012).

    Article  CAS  Google Scholar 

  8. East, S.Z., Burnet, P.W., Kerwin, R.W. & Harrison, P.J. Schizophr. Res. 57, 15–26 (2002).

    Article  CAS  Google Scholar 

  9. Grimaldi, B. et al. Naunyn Schmiedebergs Arch. Pharmacol. 357, 393–400 (1998).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Jinsoo Seo and Li-Huei Tsai are in the Picower Institute for Learning and Memory and the Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.,

    Jinsoo Seo & Li-Huei Tsai

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  1. Jinsoo Seo
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  2. Li-Huei Tsai
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Correspondence to Li-Huei Tsai.

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The authors declare no competing financial interests.

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Seo, J., Tsai, LH. 5-HT6R can do it alone. Nat Chem Biol 10, 488–489 (2014). https://doi.org/10.1038/nchembio.1557

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