A bioorthogonal decaging strategy, mediated by small-molecule palladium compounds, can recover the lysine-dependent activity of cellular proteins. This activation technique could be generally applicable for controlling and probing function of a protein target in living cells.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Schreiber, S.L. Nat. Chem. Biol. 1, 64–66 (2005).
Carlson, S.M. & White, F.M. ACS Chem. Biol. 6, 75–85 (2011).
Zorn, J.A. & Wells, J.A. Nat. Chem. Biol. 6, 179–188 (2010).
Bishop, A.C. & Chen, V.L. J. Chem. Biol. 2, 1–9 (2009).
Tarrant, M.K. & Cole, P.A. Annu. Rev. Biochem. 78, 797–825 (2009).
Li, J. et al. Nat. Chem. 6, 352–361 (2014).
Santra, M., Ko, S.K., Shin, I. & Ahn, K.H. Chem. Commun. (Camb.) 46, 3964–3966 (2010).
Garner, A.L., Song, F. & Koide, K. J. Am. Chem. Soc. 131, 5163–5171 (2009).
Liu, C.C. & Schultz, P.G. Annu. Rev. Biochem. 79, 413–444 (2010).
Muralidharan, V. & Muir, T.W. Nat. Methods 3, 429–438 (2006).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Qian, K., Zheng, Y. Palladium brings proteins to life. Nat Chem Biol 10, 328–330 (2014). https://doi.org/10.1038/nchembio.1507
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchembio.1507
