Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

DNA Damage

Walking the edge

An inhibitor of the deubiquitinase complex USP1-UAF1 highlights the requirement for reversible ubiquitination in DNA repair pathways that are critical for human development and disease.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: ML323 is a specific inhibitor of the USP1–UAF1 deubiquitylating complex.

References

  1. Ciccia, A. & Elledge, S.J. Mol. Cell 40, 179–204 (2010).

    Article  CAS  Google Scholar 

  2. Liang, Q. et al. Nat. Chem. Biol. 10, 298–304 (2014).

    Article  CAS  Google Scholar 

  3. Komander, D. & Rape, M. Annu. Rev. Biochem. 81, 203–229 (2012).

    Article  CAS  Google Scholar 

  4. Kee, Y. & D'Andrea, A.D. Genes Dev. 24, 1680–1694 (2010).

    Article  CAS  Google Scholar 

  5. Hoege, C., Pfander, B., Moldovan, G.L., Pyrowolakis, G. & Jentsch, S. Nature 419, 135–141 (2002).

    Article  CAS  Google Scholar 

  6. Bienko, M. et al. Mol. Cell 37, 396–407 (2010).

    Article  CAS  Google Scholar 

  7. Nijman, S.M. et al. Mol. Cell 17, 331–339 (2005).

    Article  CAS  Google Scholar 

  8. Huang, T.T. et al. Nat. Cell Biol. 8, 339–347 (2006).

    CAS  PubMed  Google Scholar 

  9. Kim, J.M. et al. Dev. Cell 16, 314–320 (2009).

    Article  CAS  Google Scholar 

  10. Huang, H. et al. Nat. Chem. Biol. 10, 156–163 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael Rape.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Locke, M., Rape, M. Walking the edge. Nat Chem Biol 10, 243–244 (2014). https://doi.org/10.1038/nchembio.1483

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio.1483

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer