Integration of chemistry-based approaches into enzyme engineering provides a versatile strategy for biocatalyst development with the potential for improved performance and new catalytic activities. Application of this strategy led to the development of a whole-cell catalyst capable of converting olefins into cyclopropanes, synthetic intermediates used in the synthesis of more functionalized cycloalkanes and acyclic compounds.
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Nestl, B., Hauer, B. Chemistry gets the assist. Nat Chem Biol 9, 470–471 (2013). https://doi.org/10.1038/nchembio.1291
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DOI: https://doi.org/10.1038/nchembio.1291
