Transduction of extracellular signals by cilia requires regulated entry of pathway components. A new study uses chemical dimerization to induce diffusion and identifies size-dependent soluble diffusion rates consistent with a sieve-like barrier with 8-nm pore radii at the ciliary base.
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Avasthi, P. Sifting at the ciliary base. Nat Chem Biol 9, 414–415 (2013). https://doi.org/10.1038/nchembio.1272
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DOI: https://doi.org/10.1038/nchembio.1272
