Proteins can self-assemble into functional states, or they can end up as aberrant and sometimes toxic aggregates. Metastable intermediate states are often detected in these processes, and their structural characterization provides vital information about the balance between functional and pathological behavior in living systems.
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Vendruscolo, M., Dobson, C. Protein self-assembly intermediates. Nat Chem Biol 9, 216–217 (2013). https://doi.org/10.1038/nchembio.1210
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DOI: https://doi.org/10.1038/nchembio.1210