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Membranes

First steps to rafts?

Single-molecule observations reveal that lipid- and protein-based interactions jointly contribute to the interactions among glycosylphosphatidylinositol-anchored proteins in membranes. Understanding these interactions will help to refine long-evolving (and still debated) models of 'raft' domains in biological membranes.

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Figure 1: Cholesterol and the phosphatidylinositol-glycan anchor stabilize interactions between GPI-proteins in membranes.

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Correspondence to John R Silvius.

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The author declares no competing financial interests.

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Silvius, J. First steps to rafts?. Nat Chem Biol 8, 743–744 (2012). https://doi.org/10.1038/nchembio.1045

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