Compound 1

Meldrum's Acid Conjugate Acceptor

From: Click and chemically triggered declick reactions through reversible amine and thiol coupling via a conjugate acceptor

Synthetic procedure: See article for the definitive version of this procedure and for full experimental details.

Reagent 1 was synthesized in one step, according to the literature procedure: Ben Cheikh, A. et al. Synthesis of .alpha.-cyano carbonyl compounds by flash vacuum thermolysis of (alkylamino)methylene derivatives of Meldrum’s acid. Evidence for facile 1,3-shifts of alkylamino and alkylthio groups in imidoylketene intermediates. J. Org. Chem. 56, 970–975 (1991).

PubChemID:

316894688

MDL Molfile:

41557_2016_BFnchem2601_MOESM1_ESM.mol

ChemDraw:

41557_2016_BFnchem2601_MOESM2_ESM.cdx

structure a