Fluorine imparts many drugs with beneficial properties, however, the synthesis of fluorinated complex natural products is challenging. Biosynthetic strategies and recent experimental precedents have paved the way for bioengineered fluorinated polyketides.
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Jordan, P., Moore, B. Non-stick natural products. Nature Chem 6, 10–12 (2014). https://doi.org/10.1038/nchem.1828
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DOI: https://doi.org/10.1038/nchem.1828
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