The kinase AMPK, a sensor of cellular energy stress, has been shown to oppose the growth-promoting activity of YAP, the transcriptional co-activator downstream of the Hippo signalling pathway. This finding may help to explain why the antidiabetic drug metformin, for which AMPK is a key effector, is linked to cancer-protective activity.
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References
Wang, W. et al. Nat. Cell Biol. 17, 490–499 (2015).
Mo, J-S. et al. Nat. Cell Biol. 17, 500–510 (2015).
DeRan, M. et al. Cell Rep. 9, 495–503 (2014).
Harvey, K. F., Zhang, X. & Thomas, D. M. Nat. Rev. Cancer 13, 246–257 (2013).
Yu, F. X. & Guan, K. L. Genes Dev. 27, 355–371 (2013).
Piccolo, S., Dupont, S. & Cordenonsi, M. Physiol. Rev. 94, 1287–1312 (2014).
Camargo, F. D. et al. Curr. Biol. 17, 2054–2060 (2007).
Dong, J. et al. Cell 130, 1120–1133 (2007).
Zhang, N. et al. Dev. Cell 19, 27–38 (2010).
Zhou, D. et al. Proc. Natl Acad. Sci. USA 108, E1312–E1320 (2011).
Johnson, R. & Halder, G. Nat. Rev. Drug Discov. 13, 63–79 (2014).
Liu-Chittenden, Y. et al. Genes Dev. 26, 1300–1305 (2012).
Bao, Y. et al. J. Biochem. 150, 199–208 (2011).
Hardie, D. G. Curr. Opin. Cell Biol. 33C, 1–7 (2014).
Evans, J. M., Donnelly, L. A., Emslie-Smith, A. M., Alessi, D. R. & Morris, A. D. BMJ 330, 1304–1305 (2005).
Meynet, O. & Ricci, J. E. Trends Mol. Med. 20, 419–427 (2014).
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Hariharan, I. Energy stress tames the Hippo pathway. Nat Cell Biol 17, 362–363 (2015). https://doi.org/10.1038/ncb3141
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DOI: https://doi.org/10.1038/ncb3141