Macrophages facilitate tumour progression, but it is unclear whether this capability is influenced by tumour-initiating cells. Glioblastoma stem cells are now shown to secrete periostin, a matrix protein that recruits protumoral macrophages and enhances glioblastoma progression in mice.
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Squadrito, M., De Palma, M. A niche role for periostin and macrophages in glioblastoma. Nat Cell Biol 17, 107–109 (2015). https://doi.org/10.1038/ncb3095
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DOI: https://doi.org/10.1038/ncb3095