The substrates of mammalian ULK1/2 and its yeast homologue Atg1 in autophagy have remained elusive. The class III phosphatidylinositol 3-kinase component Beclin-1 has now been identified as a physiological substrate of the ULK kinases in autophagy following amino acid starvation, therefore suggesting a critical molecular link between the upstream kinases and the autophagy core machinery.
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References
Mizushima, N. & Komatsu, M. Cell 147, 728–741 (2011).
Motley, A. M., Nuttall, J. M. & Hettema, E. H. EMBO J. 31, 2852–2868 (2012).
Mizushima, N. Curr. Opin. Cell Biol. 22, 132–139 (2010).
Russell, R. C. et al. Nat. Cell Biol. 15, 741–750 (2013).
Liang, C. et al. Nat. Cell Biol. 8, 688–699 (2006).
Itakura, E., Kishi, C., Inoue, K. & Mizushima, N. Mol. Biol. Cell 19, 5360–5372 (2008).
Sun, Q. et al. Proc. Natl Acad. Sci. USA 105, 19211–19216 (2008).
Matsunaga, K. et al. Nat. Cell Biol. 11, 385–396 (2009).
Zhong, Y. et al. Nat. Cell Biol. 11, 468–476 (2009).
Sun, Q., Westphal, W., Wong, K. N., Tan, I. & Zhong, Q. Proc. Natl Acad. Sci. USA 107, 19338–19343 (2010).
Kim, J. et al. Cell 152, 290–303 (2013).
Wang, R. C. et al. Science 338, 956–959 (2012).
Zalckvar, E. et al. EMBO Rep. 10, 285–292 (2009).
Di Bartolomeo, S. et al. J. Cell Biol. 191, 155–168 (2010).
Zhang, Y. et al. Cell 136, 308–321 (2009).
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Nazarko, V., Zhong, Q. ULK1 targets Beclin-1 in autophagy. Nat Cell Biol 15, 727–728 (2013). https://doi.org/10.1038/ncb2797
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DOI: https://doi.org/10.1038/ncb2797
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