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Osmotic regulation of seamless tube growth

Nature Cell Biology volume 15, pages 137–139 (2013)Cite this article

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Most organs are composed of tubes of differing cellular architectures, including intracellular 'seamless' tubes. Two studies examining the morphogenesis of the seamless tubes formed by the excretory canal cell in Caenorhabditis elegans reveal a previously unappreciated role for osmoregulation of tubulogenesis: hyperosmotic shock recruits canalicular vesicles to the lumenal membrane to promote seamless tube growth.

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Figure 1: Formation of seamless tubes.
Figure 2: Are canaliculi a membrane reservoir or flux capacitor?

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Authors and Affiliations

  1. Jodi Schottenfeld-Roames and Amin S. Ghabrial are in the Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, BRB II/III, Room 1214, 421 Curie Boulevard, Philadelphia, Philadelphia 19104, USA,

    Jodi Schottenfeld-Roames & Amin S. Ghabrial

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  1. Jodi Schottenfeld-Roames
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  2. Amin S. Ghabrial
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Correspondence to Amin S. Ghabrial.

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Schottenfeld-Roames, J., Ghabrial, A. Osmotic regulation of seamless tube growth. Nat Cell Biol 15, 137–139 (2013). https://doi.org/10.1038/ncb2683

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