Berger was the principal founder of Ariad and has served as its chairman and CEO for more than 20 years. Trained initially as a physician, he spent time at Centocor before starting up Ariad out of his home. Nature Biotechnology spoke to him about developing Iclusig, the difference between managing a patient's health and running a company, and how a public entity deals with bad news. http://www.nature.com/nbt/podcast/index.html