Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Complex binding sites made to order

Nature Biotechnology volume 30, pages 154–155 (2012)Cite this article

Subjects

A new computational strategy facilitates de novo design of discontinuous epitopes on protein scaffolds.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Comparison of crystal structures.

References

  1. Villen, J. et al. Chem. Biol. 13, 815–823 (2006).

    Article  CAS  Google Scholar 

  2. Irving, M.B. et al. Mol. Immunol. 47, 1137–1148 (2011).

    Article  Google Scholar 

  3. Azoitei, M.L. et al. Science 334, 373–376 (2011).

    Article  CAS  Google Scholar 

  4. Burton, D.R. et al. Science 266, 1024–1027 (1994).

    Article  CAS  Google Scholar 

  5. Zhou, T. et al. Nature 445, 732–737 (2007).

    Article  CAS  Google Scholar 

  6. Boder, E.T. & Wittrup, K.D. Nat. Biotechnol. 15, 553–557 (1997).

    Article  CAS  Google Scholar 

  7. Zwick, M.B. et al. J. Virol. 77, 5863–5876 (2003).

    Article  CAS  Google Scholar 

  8. Ofek, G. et al. Proc. Natl. Acad. Sci. USA 107, 17880–17887 (2010).

    Article  CAS  Google Scholar 

  9. Mikell, I. et al. PLoS Pathog. 7, e1001251 (2011).

    Article  CAS  Google Scholar 

  10. Breden, F. et al. PLoS ONE 6, e16857 (2011).

    Article  CAS  Google Scholar 

  11. Wu, X. Science 333, 1593–1602 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Lisa Craig and Jamie K. Scott are in the Department of Molecular Biology and Biochemistry, and Faculty of Health Sciences at Simon Fraser University, Burnaby, British Columbia, Canada.,

    Jamie K Scott & Lisa Craig

  2. Ralph Pantophlet and Jamie K. Scott are in the Faculty of Health Sciences at Simon Fraser University, Burnaby, British Columbia, Canada.,

    Jamie K Scott & Ralph Pantophlet

Authors
  1. Jamie K Scott
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ralph Pantophlet
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lisa Craig
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jamie K Scott.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Scott, J., Pantophlet, R. & Craig, L. Complex binding sites made to order. Nat Biotechnol 30, 154–155 (2012). https://doi.org/10.1038/nbt.2118

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.2118

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing