Monitored changes in the number of copies of a gene during DNA replication control the timing of sporulation in bacteria. This discovery links replication to the concept that a gene's location on a chromosome can influence cell traits.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Notes
References
Bremer, H. & Dennis, P. P. in Escherichia coli and Salmonella, Vol. 2 (ed. Neidhardt, F. C.) 1553–1569 (ASM Press, 1996).
Schmid, M. B. & Roth, J. R. J. Bacteriol. 169, 2872–2875 (1987).
Sousa, C., De Lorenzo, V. & Cebollat, A. Microbiology 143, 2071–2078 (1997).
Block, D. H. S., Hussein, R., Liang, L. W. & Lim, H. N. Nucleic Acids Res. 40, 8979–8992 (2012).
Couturier, E. & Rocha, E. P. C. Mol. Microbiol. 59, 1506–1518 (2006).
Narula, J. et al. Cell 162, 328–337 (2015).
Grimshaw, C. E. et al. Biochemistry 3, 1365–1375 (1998).
Levine, J. H., Fontes, M. E., Dworkin, J. & Elowitz, M. B. PLoS Biol. 10, e1001252 (2012).
Veening, J. W., Murray, H. & Errington, J. Genes Dev. 23, 1959–1970 (2009).
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Lazazzera, B., Hughes, D. Location affects sporulation. Nature 525, 42–43 (2015). https://doi.org/10.1038/nature15207
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature15207