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ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma

Leukemia volume 31, pages 1470–1473 (2017)Cite this article

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Burkitt lymphoma (BL) is an aggressive subtype of B-cell non-Hodgkin lymphoma that most frequently affects young children.1 BL is characterized by a chromosomal translocation involving the MYC gene locus resulting in overexpression of MYC.2 MYC is a transcription factor involved in cell growth, proliferation and maintenance of stem cell-like properties.3, 4 Besides protein-coding genes, MYC also regulates the expression of multiple microRNAs (miRNAs) and long non-coding RNAs.5, 6 In a previous study,7 we identified a MYC-related miRNA expression profile in pediatric BL as compared to MYC-low chronic lymphocytic leukemia. In this study, we further examined the role of MYC-repressed miRNAs on growth of BL cells.

Eleven miRNAs were significantly differentially expressed between Burkitt lymphoma (BL) and chronic lymphocytic leukemia (CLL) with more than fourfold difference (Supplementary Figure S1a). The differences in miRNA levels were validated by quantitative reverse transcription PCR (qRT-PCR), and MYC regulation was confirmed using the P493-6 B-cell line, which harbors a tetracycline-repressible myc allele8 (Supplementary Figures S1b–d).

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References

  1. Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994; 84: 1361–1392.

    CAS  PubMed  Google Scholar 

  2. Molyneux EM, Rochford R, Griffin B, Newton R, Jackson G, Menon G et al. Burkitt's lymphoma. Lancet 2012; 379: 1234–1244.

    Article  Google Scholar 

  3. Singh AM, Dalton S . The cell cycle and Myc intersect with mechanisms that regulate pluripotency and reprogramming. Cell Stem Cell 2009; 5: 141–149.

    Article  CAS  Google Scholar 

  4. Yap CS, Peterson AL, Castellani G, Sedivy JM, Neretti N . Kinetic profiling of the c-Myc transcriptome and bioinformatic analysis of repressed gene promoters. Cell Cycle 2011; 10: 2184–2196.

    Article  CAS  Google Scholar 

  5. Winkle M, van den Berg A, Tayari M, Sietzema J, Terpstra M, Kortman G et al. Long noncoding RNAs as a novel component of the Myc transcriptional network. FASEB J 2015; 29: 2338–2346.

    Article  CAS  Google Scholar 

  6. Chang TC, Yu D, Lee YS, Wentzel EA, Arking DE, West KM et al. Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet 2008; 40: 43–50.

    Article  CAS  Google Scholar 

  7. Robertus JL, Kluiver J, Weggemans C, Harms G, Reijmers RM, Swart Y et al. MiRNA profiling in B non-Hodgkin lymphoma: a MYC-related miRNA profile characterizes Burkitt lymphoma. Br J Haematol 2010; 149: 896–899.

    Article  CAS  Google Scholar 

  8. Pajic A, Spitkovsky D, Christoph B, Kempkes B, Schuhmacher M, Staege MS et al. Cell cycle activation by c-myc in a Burkitt lymphoma model cell line. Int J Cancer 2000; 87: 787–793.

    Article  CAS  Google Scholar 

  9. He Y, Jiang X, Chen J . The role of miR-150 in normal and malignant hematopoiesis. Oncogene 2014; 33: 3887–3893.

    Article  CAS  Google Scholar 

  10. Xiao C, Calado DP, Galler G, Thai TH, Patterson HC, Wang J et al. MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell 2007; 131: 146–159.

    Article  CAS  Google Scholar 

  11. Korycka J, Lach A, Heger E, Boguslawska DM, Wolny M, Toporkiewicz M et al. Human DHHC proteins: a spotlight on the hidden player of palmitoylation. Eur J Cell Biol 2012; 91: 107–117.

    Article  CAS  Google Scholar 

  12. Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK et al. Natural RNA circles function as efficient microRNA sponges. Nature 2013; 495: 384–388.

    Article  CAS  Google Scholar 

  13. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature 2013; 495: 333–338.

    Article  CAS  Google Scholar 

  14. Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP . A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell 2011; 146: 353–358.

    Article  CAS  Google Scholar 

  15. Yu L, Reader JC, Chen C, ZhaSo XF, Ha JS, Lee C et al. Activation of a novel palmitoyltransferase ZDHHC14 in acute biphenotypic leukemia and subsets of acute myeloid leukemia. Leukemia 2011; 25: 367–371.

    Article  CAS  Google Scholar 

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Acknowledgements

This work was supported by SKOG grants 11-001 (to JK and AvdB) and 14-001 (to JK, KK and AvdB).

Author contributions

AD-K, JK, KK and AvdB planned and supervised the project; AD-K, JK, IS-P, J-LR, JB, MMT, BR, DdJ, JK, AS and BT collected the data; analysis was carried out by AD-K, JK, IMN and JL; AD revised the pathological tissues; JEG contributed the tissue specimens; and AD-K, JK and AvdB with help of AD, LV and KK prepared the manuscript.

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Author notes

  1. J Kluiver and A van den Berg: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Pathology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

    A Dzikiewicz-Krawczyk, I Slezak-Prochazka, J-L Robertus, J Bruining, M M Tayari, B Rutgers, D de Jong, J Koerts, A Seitz, B Tillema, A Diepstra, L Visser, J Kluiver & A van den Berg

  2. lnstitute of Human Genetics, Polish Academy of Sciences, Poznan, Poland

    A Dzikiewicz-Krawczyk

  3. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

    K Kok & J Li

  4. Biosystems Group, Institute of Automatic Control, Silesian University of Technology, Gliwice, Poland

    I Slezak-Prochazka

  5. Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    J E Guikema

  6. Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

    I M Nolte

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  1. A Dzikiewicz-Krawczyk
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Correspondence to J Kluiver or A van den Berg.

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Dzikiewicz-Krawczyk, A., Kok, K., Slezak-Prochazka, I. et al. ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma. Leukemia 31, 1470–1473 (2017). https://doi.org/10.1038/leu.2017.94

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