Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter to the Editor
  • Published:

The role of PAX5 and C/EBP α/β in atypical non-Langerhans cell histiocytic tumor post acute lymphoblastic leukemia

Leukemia volume 28, pages 1377–1379 (2014)Cite this article

Subjects

An Erratum to this article was published on 04 June 2014

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

References

  1. Castro EC, Blazquez C, Boyd J, Correa H, de Chadarevian JP, Felgar RE et al. Clinicopathologic features of histiocytic lesions following ALL, with a review of the literature. Pediatr Dev Pathol 2010; 13: 225–237.

    Article  PubMed  Google Scholar 

  2. Tijchon E, Havinga J, van Leeuwen FN, Scheijen B . B-lineage transcription factors and cooperating gene lesions required for leukemia development. Leukemia 2013; 27: 541–552.

    Article  CAS  PubMed  Google Scholar 

  3. Simmons S, Knoll M, Drewell C, Wolf I, Mollenkopf HJ, Bouquet C et al. Biphenotypic B-lymphoid/myeloid cells expressing low levels of Pax5: potential targets of BAL development. Blood 2012; 120: 3688–3698.

    Article  CAS  PubMed  Google Scholar 

  4. Greaves MF . Differentiation-linked leukemogenesis in lymphocytes. Science 1986; 234: 697–704.

    Article  CAS  PubMed  Google Scholar 

  5. Cobaleda C, Busslinger M . Developmental plasticity of lymphocytes. Curr Opin Immunol 2008; 20: 139–148.

    Article  CAS  PubMed  Google Scholar 

  6. Conter V, Bartram CR, Valsecchi MG, Schrauder A, Panzer-Grümayer R, Möricke A et al. Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study. Blood 2010; 115: 3206–3214.

    Article  CAS  PubMed  Google Scholar 

  7. Ivan D, Neto A, Lemos L, Gupta A . Erdheim-Chester disease: a unique presentation with liver involvement and vertebral osteolytic lesions. Arch Pathol Lab Med 2003; 127: 337–339.

    Google Scholar 

  8. Haroche J, Cohen-Aubart F, Emile JF, Arnaud L, Maksud P, Charlotte F et al. Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation. Blood 2013; 121: 1495–1500.

    Article  CAS  PubMed  Google Scholar 

  9. Naik SH, Perié L, Swart E, Gerlach C, van Rooij N, de Boer RJ et al. Diverse and heritable lineage imprinting of early haematopoietic progenitors. Nature 2013; 496: 229–232.

    Article  CAS  PubMed  Google Scholar 

  10. Mullighan CG, Phillips LA, Su X, Ma J, Miller CB, Shurtleff SA et al. Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia. Science 2008; 322: 1377–1380.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Rapino F, Robles EF, Richter-Larrea JA, Kallin EM, Martinez-Climent JA, Graf T . C/EBPα induces highly efficient macrophage transdifferentiation of B lymphoma and leukemia cell lines and impairs their tumorigenicity. Cell Rep 2013; 3: 1153–1163.

    Article  CAS  PubMed  Google Scholar 

  12. Stoilova B, Kowenz-Leutz E, Scheller M, Leutz A . Lymphoid to myeloid cell trans-differentiation is determined by C/EBPβ structure and post-translational modifications. PLoS One 2013; 8: e65169.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Livak K, Schmittgen TD . Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402–408.

    Article  CAS  PubMed  Google Scholar 

  14. Slamova L, Starkova J, Fronkova E, Zaliova M, Reznickova L, van Delft FW et al. CD2-positive B-cell precursor acute lymphoblastic leukemia with an early switch to the monocytic lineage. Leukemia 2014; 28: 609–620.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This research was partially supported by AIRC to G Cazzaniga and AB, AIRC ‘5 per mille’ to AB, and also by grants from Ministero Italiano dell’Università e della Ricerca and Ministero della Salute to AB.

Author information

Author notes

  1. F Pagni and G Fazio: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Surgery and Interdisciplinary Medicine, Pathology Section, University Milano-Bicocca, Milan, Italy

    F Pagni, S Zannella, C Cusi, G Isimbaldi & G Cattoretti

  2. Centro Ricerca Tettamanti, Pediatric Clinic, University of Milan Bicocca, San Gerardo Hospital/Fondazione MBBM, Monza, Italy

    G Fazio, L Corral, C Bugarin & G Cazzaniga

  3. Department of Health Sciences, University of Milan Bicocca, Monza, Italy

    G Fazio

  4. Pediatric Clinic, University of Milan Bicocca, San Gerardo Hospital/Fondazione MBBM, Monza, Italy

    M Spinelli, C De Angelis & A Biondi

  5. Department of Genetics, Department of Surgical Pathology, San Gerardo Hospital, Monza, Italy

    F Crosti

Authors
  1. F Pagni
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G Fazio
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S Zannella
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M Spinelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C De Angelis
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C Cusi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. F Crosti
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. L Corral
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. C Bugarin
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. A Biondi
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. G Cazzaniga
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. G Isimbaldi
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. G Cattoretti
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G Cazzaniga.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Additional information

Supplementary Information accompanies this paper on the Leukemia website

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pagni, F., Fazio, G., Zannella, S. et al. The role of PAX5 and C/EBP α/β in atypical non-Langerhans cell histiocytic tumor post acute lymphoblastic leukemia. Leukemia 28, 1377–1379 (2014). https://doi.org/10.1038/leu.2014.87

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/leu.2014.87

This article is cited by

Search

Advanced search

Quick links