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Identification of activated Tnk1 kinase in Hodgkin's lymphoma

Leukemia volume 24, pages 861–865 (2010)Cite this article

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Protein tyrosine kinases are important regulators of intracellular signal-transduction pathways mediating cellular proliferation, survival and development. The activity of these kinases is normally tightly regulated, and constitutive activation of tyrosine kinases by acquired somatic mutation contributes to oncogenic transformation in many types of tumors. Hodgkin's lymphoma (HL) is one of the most common lymphomas in the world, characterized by the presence of Reed-Sternberg cells. Reed-Sternberg cells show deregulation of multiple signaling pathways and transcription factors, including receptor tyrosine kinases, JAK/STAT and nuclear factor-κB.1

Although the signaling pathways regulated by TNK1 are largely unknown, it was shown to have a negative regulatory role in the Ras–Raf1–MAPK pathway. Tnk1 knockout mice have been shown to develop spontaneous tumors,5 suggesting a role as a tumor suppressor gene. In addition, activation of TNK1 enables tumor necrosis factor-α-induced apoptosis by preventing activation of nuclear factor-κB.6

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Acknowledgements

We thank Lori Wetzel, Julie Nardone, Joan MacNeill and Jianmin Ren for technical assistances.

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  1. Department of Research, Cell Signaling Technology Inc., Danvers, MA, USA

    T-L Gu, J Cherry, M Tucker, J Wu, C Reeves & R D Polakiewicz

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  1. T-L Gu
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  2. J Cherry
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  3. M Tucker
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  4. J Wu
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  5. C Reeves
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  6. R D Polakiewicz
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Correspondence to T-L Gu.

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TLG, JC, MT, JW, CR and RDP are employees of Cell Signaling Technology Inc.

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Gu, TL., Cherry, J., Tucker, M. et al. Identification of activated Tnk1 kinase in Hodgkin's lymphoma. Leukemia 24, 861–865 (2010). https://doi.org/10.1038/leu.2009.293

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