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Association between maternal inflammatory bowel disease and adverse perinatal outcomes

Journal of Perinatology volume 34, pages 435–440 (2014)Cite this article

Subjects

Abstract

Objective:

To examine whether inflammatory bowel disease (IBD) is associated with ischemic/inflammatory conditions during pregnancy.

Study Design:

A retrospective cohort study using the 2000 to 2012 Kaiser Permanente Southern California maternally-linked medical records (n=395 781). The two major subtypes of IBD, ulcerative colitis and Crohn’s diseases were studied. Adjusted odds ratios (ORs) were used to quantify the associations.

Result:

A pregnancy complicated by IBD was associated with increased incidence of small-for-gestational age birth (OR=1.46, 95% confidence interval (CI)=1.14 to 1.88), spontaneous preterm birth (OR=1.32, 95% CI=1.00 to 1.76) and preterm premature rupture of membranes (OR=1.95, 95% CI=1.26 to 3.02). Further stratifying by IBD subtypes, only ulcerative colitis was significantly associated with increased incidence of ischemic placental disease, spontaneous preterm birth and preterm premature rupture of membranes.

Conclusion:

The findings underscore the potential impact of maternal IBD on adverse perinatal outcomes. Clinicians should be aware that the association between IBD and adverse perinatal outcome varies by IBD subtypes.

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Acknowledgements

The authors thank Daniel J Pinion for his technical support. This study was supported by Kaiser Permanente Direct Community Benefit Funds.

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Authors and Affiliations

  1. Department of Research & Evaluation, Kaiser Permanente Southern California Medical Group, Pasadena, CA, USA

    D Getahun, G F Longstreth, C Koebnick, A M Langer-Gould, D Strickland & S J Jacobsen

  2. Department of Obstetrics and Gynecology, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA

    D Getahun

  3. Department of Maternal-Fetal Medicine, West Los Angeles Medical Center, Kaiser Permanente Southern California Medical Group, Pasadena, CA, USA

    M J Fassett

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  1. D Getahun
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Correspondence to D Getahun.

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Getahun, D., Fassett, M., Longstreth, G. et al. Association between maternal inflammatory bowel disease and adverse perinatal outcomes. J Perinatol 34, 435–440 (2014). https://doi.org/10.1038/jp.2014.41

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  • DOI: https://doi.org/10.1038/jp.2014.41

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