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Relationship between C242T polymorphism and arterial stiffness in an apparently healthy population

Journal of Human Hypertension volume 30, pages 488–492 (2016)Cite this article

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Abstract

Superoxide production is modulated by the C242T polymorphism of the CYBA gene. A major source of the superoxide anion that contributes to arterial stiffness is oxidase. We investigated the relationship between the C242T polymorphism and brachial-ankle pulse wave velocity (baPWV) in an apparently healthy population, while controlling for the amount of consumed cigarette. We measured baPWV non-invasively, recorded the detailed history of smoking and genotyped the C242T polymorphism in 856 participants. The CC genotype was related to a higher value of baPWV than the CT/TT genotype (1438.7±11.9 vs 1371.0±32.4 cm s−1, β=−0.069, P=0.03) after adjustment for covariates. Further investigation showed an interaction between C242T polymorphism and smoking status with respect to baPWV (P<0.0001). For smokers, the CC genotype of C242T polymorphism was correlated with higher baPWV values compared with CT/TT genotype (1344.2±17.4 vs 1126.8±22.5 cm s−1, β=−0.279, P<0.0001), whereas this relationship in the non-smokers was not significant (1485.5±15.1 vs 1499.0±41.5 cm s−1, β=0.027, P=0.48). Additionally, for smokers who smoked at least 180 cigarette-years, the CC genotype participants showed higher values of baPWV compared with CT/TT polymorphism carriers (P⩽0.011). Our findings suggest that the C242T gene polymorphism is associated with arterial stiffness. Additionally, this relationship could be modified by smoking dose.

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Acknowledgements

The study was supported by grants from the Health Bureau of Changzhou, China (ZD201314).

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Authors and Affiliations

  1. Department of Cardiology, Changzhou Second People’s Hospital, Affiliated Nanjing Medical University, Changzhou, China

    Y Ji, J Ge, F Wang, J Jiang & H Cao

  2. Department of Cardiology, The First People’s Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, China

    Z Zhu

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Correspondence to J Ge.

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Ji, Y., Ge, J., Zhu, Z. et al. Relationship between C242T polymorphism and arterial stiffness in an apparently healthy population. J Hum Hypertens 30, 488–492 (2016). https://doi.org/10.1038/jhh.2015.108

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