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Relation of dietary inorganic arsenic to serum matrix metalloproteinase-9 (MMP-9) at different threshold concentrations of tap water arsenic

Journal of Exposure Science & Environmental Epidemiology volume 26, pages 445–451 (2016)Cite this article

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Abstract

Arsenic (As) exposure is associated with cancer, lung and cardiovascular disease, yet the mechanisms involved are not clearly understood. Elevated matrix metalloproteinase-9 (MMP-9) levels are also associated with these diseases, as well as with exposure to water As. Our objective was to evaluate the effects of dietary components of inorganic As (iAs) intake on serum MMP-9 concentration at differing levels of tap water As. In a cross-sectional study of 214 adults, dietary iAs intake was estimated from 24-h dietary recall interviews using published iAs residue data; drinking and cooking water As intake from water samples and consumption data. Aggregate iAs intake (food plus water) was associated with elevated serum MMP-9 in mixed model regression, with and without adjustment for covariates. In models stratified by tap water As, aggregate intake was a significant positive predictor of serum MMP-9 in subjects exposed to water As≤10 μg/l. Inorganic As from food alone was associated with serum MMP-9 in subjects exposed to tap water As≤3 μg/l. Exposure to iAs from food and water combined, in areas where tap water As concentration is ≤10 μg/l, may contribute to As-induced changes in a biomarker associated with toxicity.

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Acknowledgements

This research was supported in part by U.S. EPA Star Grant # R83399201-0, the University of Arizona Specialized Program of Research Excellence (SPORE) (NIH/NCI Grant # CA95060) and the Southwest Environmental Health Sciences Center (NIEHS Grant # ES06694).

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Authors and Affiliations

  1. Department of Pediatrics, University of Arizona, College of Medicine, Tucson, Arizona, USA

    Margaret Kurzius-Spencer

  2. University of Arizona, Mel & Enid Zuckerman College of Public Health, Tucson, Arizona, USA

    Margaret Kurzius-Spencer, Robin B Harris, Chiu-Hsieh Hsu, Mary Kay O'Rourke & Jefferey L Burgess

  3. University of Arizona, Arizona Cancer Center, Tucson, Arizona, USA

    Robin B Harris, Vern Hartz & Chiu-Hsieh Hsu

  4. Carolinas Healthcare System, Dickson Advanced Analytics Group, Charlotte, North Carolina, USA

    Jason Roberge

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Kurzius-Spencer, M., Harris, R., Hartz, V. et al. Relation of dietary inorganic arsenic to serum matrix metalloproteinase-9 (MMP-9) at different threshold concentrations of tap water arsenic. J Expo Sci Environ Epidemiol 26, 445–451 (2016). https://doi.org/10.1038/jes.2014.92

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