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Reproducibility of urinary bisphenol A concentrations measured during pregnancy in the Generation R Study

Journal of Exposure Science & Environmental Epidemiology volume 24, pages 532–536 (2014)Cite this article

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Abstract

The potential human health effects of bisphenol A (BPA) exposure are a public health concern. In order to design adequately powered epidemiological studies to address potential health effects, data on the reproducibility of BPA concentration in serial urine specimens taken during pregnancy are needed. To provide additional data on the reproducibility of maternal urine specimens, 80 women in the Generation R Study (Rotterdam, The Netherlands) contributed a spot urine specimen at <18, 18–25, and >25 weeks of pregnancy. Reproducibility, estimated by the intraclass correlation coefficient (ICC), was 0.32 (95% confidence interval: 0.18–0.46), and, on a creatinine basis, 0.31 (95% confidence interval: 0.16–0.47). Although the ICC observed in the Generation R Study is slightly higher than previous reproducibility studies of BPA, it nevertheless indicates a high degree of within-person variability that presents challenges for designing well-powered epidemiologic studies.

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Acknowledgements

We thank Joe Braun for providing additional results from the EARTH study, and Walter Rogan and Jane Hoppin who provided comments on an earlier draft of the manuscript. We also thank Kelly Thevenet-Morrison who provided programming assistance. This research received support from the Intramural Research Program of the National Institutes of Health, National Institute of Environmental Health Sciences, the Erasmus Medical Center and Erasmus University Rotterdam, The Netherlands Organization for Health Research and Development (ZonMw), and from NIH grants K12 ES019852 and P30 ES001247.

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Authors and Affiliations

  1. Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, 265 Crittenden Boulevard, Rochester, New York, USA

    Todd A Jusko

  2. Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, 423 Guardian Drive, Philadelphia, Pennsylvania, USA

    Pamela A Shaw

  3. Department of Public Health, Erasmus Medical Center, Rotterdam, 3000, CA, The Netherlands

    Claudia A Snijder & Alex Burdorf

  4. The Generation R Study Group, Erasmus Medical Center, Erasmus Medical Centre, Rotterdam, 3000, CA, The Netherlands

    Claudia A Snijder & Vincent W V Jaddoe

  5. Department of Urban Environment and Safety, TNO (Netherlands Organization for Applied Scientific Research), Princetonlaan 6, Utrecht, 3584, CB, The Netherlands

    Frank H Pierik

  6. Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, Bochum, 44789, Germany

    Holger M Koch

  7. Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts, USA

    Russ Hauser

  8. Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3000, DR, The Netherlands

    Vincent W V Jaddoe & Albert Hofman

  9. Department of Pediatrics, Erasmus Medical Center, Rotterdam, 3000, CB, The Netherlands

    Vincent W V Jaddoe

  10. Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, 3000, CA, The Netherlands

    Henning Tiemeier

  11. Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, 111 T.W. Alexander Drive, Research Triangle Park, North Carolina, USA

    Matthew P Longnecker

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  1. Todd A Jusko
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  5. Holger M Koch
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  6. Russ Hauser
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  7. Vincent W V Jaddoe
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Correspondence to Todd A Jusko.

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Jusko, T., Shaw, P., Snijder, C. et al. Reproducibility of urinary bisphenol A concentrations measured during pregnancy in the Generation R Study. J Expo Sci Environ Epidemiol 24, 532–536 (2014). https://doi.org/10.1038/jes.2014.23

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