Abstract
YM-216391, a novel cytotoxic cyclic peptide, has been isolated from the cultured mycelium of Streptomyces nobilis JCM 4274. The planar structure of YM-216391 was assigned on the basis of 1D and 2D NMR spectroscopic techniques. The absolute configuration of the amino acid residues in YM-216391 was determined by Marfey's analysis and chiral HPLC analysis of its acid hydrolysate.
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Sohda K, Nagai K, Yamori T, Suzuki K, Tanaka A . YM-216391, a novel cytotoxic cyclic peptide from Streptomyces nobilis. I. Fermentation, isolation and biological activities. J Antibiot 58: 27–31 ( 2005)
Roesener JA, Scheuer PJ . Ulapualide A and B, extraordinary antitumor macrolides from nudibranch eggmasses. J Am Chem Soc 108: 846–847 ( 1986)
Matsunaga S, Fusetani N, Hashimoto K . Kabiramide C, a novel antifungal macrolide from nudibranch eggmasses. J Am Chem Soc 108: 847–849 ( 1986)
Hiemstra H, Houwing HA, Possel O, van Leusen AM . Carbon-13 nuclear magnetic resonance spectra of oxazoles. Can J Chem 57: 3168–3170 ( 1979)
Marfey P . Determination of D-amino acids II Use of a bifunctional reagent, 1,5-difluoro-2,4-dinitrobenzene. Carlsberg Res Comm 49: 591–596 ( 1984)
Shin-ya K, Wierzba K, Matsuo K, Ohtani T, Yamada Y, Furihata K, Hayakawa Y, Seto H . Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus. J Am Chem Soc 123: 1262–1263 ( 2001)
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Sohda, Ky., Hiramoto, M., Suzumura, Ki. et al. YM-216391, a Novel Cytotoxic Cyclic Peptide from Streptomyces nobilis. J Antibiot 58, 32–36 (2005). https://doi.org/10.1038/ja.2005.3
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DOI: https://doi.org/10.1038/ja.2005.3
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