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Association between periodontal disease and polycystic ovary syndrome: a systematic review

International Journal of Impotence Research volume 29, pages 89–95 (2017)Cite this article

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Abstract

The purpose of the present study was to review systematically the association between periodontal diseases (PDs) and polycystic ovary syndrome (PCOS). To address the focused question, ‘Is there a relationship between PD and PCOS?’ indexed databases were searched up to October 2016 without time or language restrictions using different combinations of the following key words: PCOS, ovarian cysts, PD, periodontitis, gingival diseases and gingivitis. Letters to the Editor, commentaries, historic reviews, case-report, unpublished articles and animal/experimental studies were excluded. Seven case–control studies were included. The number of study participants ranged between 52 and 196 females aged between 15 and 45 years. In three and three studies, proinflammatory cytokines were assessed in gingival crevicular fluid and saliva samples, respectively. In one study, salivary microbes were investigated. All studies reported that a positive association exists between PD and PCOS. In conclusion, there is a positive association between PD and PCOS; however, further well-designed longitudinal controlled clinical trials are needed in this regard. It is recommended that physicians should refer patients with PCOS to oral health-care providers for comprehensive oral evaluation and treatment.

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Acknowledgements

The authors extend their appreciation to the International Scientific Partnership Program (ISPP) at King Saud University, Riyadh, Saudi Arabia for funding this research work through ISPP No. 0075.

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Authors and Affiliations

  1. Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA

    S V Kellesarian, H Malmstrom & F Javed

  2. Department of General Dentistry, Faculty of Dentistry, Universidad Santa Maria, Caracas, Venezuela

    S V Kellesarian & V R Malignaggi

  3. Department of Health Services Administration, College of Nursing and Health Sciences, Barry University, Miami, FL, USA

    T V Kellesarian

  4. Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia

    A A Al-Kheraif

  5. Dental Department, King Abdulaziz University Hospital, King Saud University, Riyadh, Saudi Arabia

    M M Alwageet

  6. Department of Oral Surgery and Implant Dentistry, Dental School, Johann Wolfgang Goethe, University of Frankfurt, Frankfurt, Germany

    G E Romanos

  7. Department of Periodontology, School of Dental Medicine, Stony Brook University, Stony Brook, NY, USA

    G E Romanos

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  1. S V Kellesarian
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Corresponding author

Correspondence to S V Kellesarian.

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Appendix 1

Appendix 1

List of excluded articles

  1. i

    Asnani KP, Hingorani D, Kheur S, Deshmukh V, Romanos GE. Expression of nuclear receptors of gingiva in polycystic ovarian syndrome: a preliminary case study. Aust Dent J 2014; 59: 252–257 (case-report design).

  2. ii

    Greenhill C. Reproductive endocrinology: PCOS raises risk of periodontitis. Nat Rev Endocrinol 2010; 6: 656 (comment).

  3. iii

    Mattout P, Pelissier H, Codaccioni M. Histological study of dental and periodontal inclusions in a dermoid cyst of the ovary. J Parodontol 1985; 4: 55–62 (focus question was not answered).

  4. iv

    Levin HL. Some dental aspects of endocrine diseases. Oral Surg Oral Med Oral Pathol Oral Radiol 1965; 19: 466–477.

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Kellesarian, S., Malignaggi, V., Kellesarian, T. et al. Association between periodontal disease and polycystic ovary syndrome: a systematic review. Int J Impot Res 29, 89–95 (2017). https://doi.org/10.1038/ijir.2017.7

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