Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Effect of functional yogurt NY-YP901 in improving the trait of metabolic syndrome

European Journal of Clinical Nutrition volume 65, pages 1250–1255 (2011)Cite this article

Subjects

Abstract

Background/Objectives:

This study was aimed to assess the beneficial effects on metabolic syndrome of functional yogurt NY-YP901 (Namyang Dairy Product Co. Ltd and Nutra R&BT Inc., Seoul, Korea) supplemented with mixture of Streptococcus thermophilus, Lactobacillus acidophilus, Bifidobacterium infantis and extra-ingredients containing Bifidobacterium breve (CBG-C2), Enterococcus faecalis FK-23, fibersol-2 and so on.

Subjects/Methods:

This study was designed as an 8-week randomized, double-blind, placebo-controlled, parallel study. Treatment and control groups consumed a functional yogurt NY-YP901 (150 ml) and a placebo yogurt twice a day, respectively, for 8 weeks. Body weight and body mass index (BMI), blood pressure, lipid profiles, fasting glucose with HbA1C and waist circumference were measured before and after treatment. Inclusion criteria were healthy individuals between the ages 20–65 years old who submitted an informed consent.

Results:

During the period August 2009 to December 2009, 101 healthy participants (31 males and 70 females) finished the study. Treatment group were 53 individuals, and the control group were 48 individuals. In the treatment group consuming NY-YP901, statistically significant beneficial changes were observed in body weight (treatment group vs control group=−0.24±1.50 vs +0.64±1.39 kg, P<0.05), BMI (−0.10±0.58 vs +0.24±0.50 kg/m2, P<0.05 ) and low-density lipoprotein (LDL)-cholesterol (−7.71±14.14 vs −0.43±15.32 mg/dl, P<0.05) after 8 weeks. The change in other parameters was not different between the treatment and the control groups.

Conclusions:

The functional yogurt NY-YP901 reduced LDL-cholesterol, body weight and BMI in the subjects at a 300-ml consumption daily for 8 weeks. From these findings, regular intake of functional yogurt NY-YP901 may be consequently related to improve metabolic syndrome.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  • Agerholm-Larsen L, Raben A, Haulrik N, Hansen AS, Manders M, Astrup A (2000). Effect of 8 week intake of probiotic milk products on risk factors for cardiovascular diseases. Eur J Clin Nutr 54, 288–297.

    Article  CAS  Google Scholar 

  • Blade C, Arola L, Salvado MJ (2010). Hypolipidemic effects of proanthocyanidins and their underlying biochemical and molecular mechanisms. Mol Nutr Food Res 54, 37–59.

    Article  CAS  Google Scholar 

  • Blankson H, Stakkestad JA, Fagertun H, Thom E, Wadstein J, Gudmundsen O (2000). Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr 130, 2943–2948.

    Article  CAS  Google Scholar 

  • Fastinger ND, Karr-Lilienthal LK, Spears JK, Swanson KS, Zinn KE, Nava GM et al. (2008). A novel resistant maltodextrin alters gastrointestinal tolerance factors, fecal characteristics, and fecal microbiota in healthy adult humans. J Am Coll Nutr 27, 356–366.

    Article  CAS  Google Scholar 

  • Frid AH, Nilsson M, Holst JJ, Bjorck IM (2005). Effect of whey on blood glucose and insulin responses to composite breakfast and lunch meals in type 2 diabetic subjects. Am J Clin Nutr 82, 69–75.

    Article  CAS  Google Scholar 

  • Goldin BR, Gorbach SL (2008). Clinical indications for probiotics: an overview. Clin Infect Dis 46 (Suppl 2), S96–S100; discussion S144--S151.

    Article  Google Scholar 

  • Harwood Jr HJ, Chandler CE, Pellarin LD, Bangerter FW, Wilkins RW, Long CA et al. (1993). Pharmacologic consequences of cholesterol absorption inhibition: alteration in cholesterol metabolism and reduction in plasma cholesterol concentration induced by the synthetic saponin beta-tigogenin cellobioside (CP-88818; tiqueside). J Lipid Res 34, 377–395.

    CAS  PubMed  Google Scholar 

  • Hayakawa K, Kimura M, Kamata K (2002). Mechanism underlying gamma-aminobutyric acid-induced antihypertensive effect in spontaneously hypertensive rats. Eur J Pharmacol 438, 107–113.

    Article  CAS  Google Scholar 

  • Inoue K, Shirai T, Ochiai H, Kasao M, Hayakawa K, Kimura M et al. (2003). Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 57, 490–495.

    Article  CAS  Google Scholar 

  • Jauhiainen T, Korpela R (2007). Milk peptides and blood pressure. J Nutr 137, 825S–829S.

    Article  CAS  Google Scholar 

  • Jeon JR, Kim JY (2006). Effects of pine needle extract on differentiation of 3T3-L1 preadipocytes and obesity in high-fat diet fed rats. Biol Pharm Bull 29, 2111–2115.

    Article  CAS  Google Scholar 

  • Kawase M, Hashimoto H, Hosoda M, Morita H, Hosono A (2000). Effect of administration of fermented milk containing whey protein concentrate to rats and healthy men on serum lipids and blood pressure. J Dairy Sci 83, 255–263.

    Article  CAS  Google Scholar 

  • Kennedy A, Martinez K, Schmidt S, Mandrup S, LaPoint K, McIntosh M (2010). Antiobesity mechanisms of action of conjugated linoleic acid. J Nutr Biochem 21, 171–179.

    Article  CAS  Google Scholar 

  • Kim SW, Park SK, Kang SI, Kang HC, Oh HJ, Bae CY et al. (2003). Hypocholesterolemic property of Yucca schidigera and Quillaja saponaria extracts in human body. Arch Pharm Res 26, 1042–1046.

    Article  CAS  Google Scholar 

  • Kim YM, Jeong YK, Wang MH, Lee WY, Rhee HI (2005). Inhibitory effect of pine extract on alpha-glucosidase activity and postprandial hyperglycemia. Nutrition 21, 756–761.

    Article  CAS  Google Scholar 

  • Kishimoto Y, Oga H, Tagami H, Okuma K, Gordon DT (2007). Suppressive effect of resistant maltodextrin on postprandial blood triacylglycerol elevation. Eur J Nutr 46, 133–138.

    Article  CAS  Google Scholar 

  • Le NA, Walter MF (2007). The role of hypertriglyceridemia in atherosclerosis. Curr Atheroscler Rep 9, 110–115.

    Article  CAS  Google Scholar 

  • Lee JS, Ahn KH, Park KJ (2005). Ameliorative effect of pine needle oil on liver protection and lipid metabolism of alcohol fed rats. Food Sci Biotechnol 14 (1), 99–101.

    Google Scholar 

  • Liong MT (2007). Probiotics: a critical review of their potential role as antihypertensives, immune modulators, hypocholesterolemics, and perimenopausal treatments. Nutr Rev 65, 316–328.

    Article  Google Scholar 

  • Luhovyy BL, Akhavan T, Anderson GH (2007). Whey proteins in the regulation of food intake and satiety. J Am Coll Nutr 26, 704S–712S.

    Article  CAS  Google Scholar 

  • Lye HS, Kuan CY, Ewe JA, Fung WY, Liong MT (2009). The improvement of hypertension by probiotics: effects on cholesterol, diabetes, renin, and phytoestrogens. Int J Mol Sci 10, 3755–3775.

    Article  CAS  Google Scholar 

  • Miguel M, Recio I, Ramos M, Delgado MA, Aleixandre MA (2006). Antihypertensive effect of peptides obtained from Enterococcus faecalis-fermented milk in rats. J Dairy Sci 89, 3352–3359.

    Article  CAS  Google Scholar 

  • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2002). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 106, 3143–3421.

    Article  Google Scholar 

  • Okita Y, Nakamura H, Kouda K, Takahashi I, Takaoka T, Kimura M et al. (2009). Effects of vegetable containing gamma-aminobutyric acid on the cardiac autonomic nervous system in healthy young people. J Physiol Anthropol 28, 101–107.

    Article  Google Scholar 

  • Pereira DI, Gibson GR (2002). Effects of consumption of probiotics and prebiotics on serum lipid levels in humans. Crit Rev Biochem Mol Biol 37, 259–281.

    Article  CAS  Google Scholar 

  • Pfeuffer M, Schrezenmeir J (2007). Milk and the metabolic syndrome. Obes Rev 8, 109–118.

    Article  CAS  Google Scholar 

  • Rapp RJ (2002). Hypertriglyceridemia: a review beyond low-density lipoprotein. Cardiol Rev 10, 163–172.

    Article  Google Scholar 

  • Seppo L, Jauhiainen T, Poussa T, Korpela R (2003). A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects. Am J Clin Nutr 77, 326–330.

    Article  CAS  Google Scholar 

  • Shimada M, Hasegawa T, Nishimura C, Kan H, Kanno T, Nakamura T et al. (2009). Anti-hypertensive effect of gamma-aminobutyric acid (GABA)-rich Chlorella on high-normal blood pressure and borderline hypertension in placebo-controlled double blind study. Clin Exp Hypertens 31, 342–354.

    Article  CAS  Google Scholar 

  • Xiao JZ, Kondo S, Takahashi N, Miyaji K, Oshida K, Hiramatsu A et al. (2003). Effects of milk products fermented by Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers. J Dairy Sci 86, 2452–2461.

    Article  CAS  Google Scholar 

  • Yim MH, Hong TG, Lee JH (2006). Antioxidant and antimicrobial activities of fermentation and ethanol extracts of pine needles (Pinus densiflora). Food Sci Biotechnol 15, 582–588.

    Google Scholar 

  • Kishimoto Y, Yoshikawa Y, Miyazato S, Oga H, Yamada T, Tagami H et al. (2009). Effect of resistant maltodextrin on digestion and absorption of lipids. J Health Sci 55, 838–844.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This study was supported by Seoul Research and Business Development Program (No. 10582). Namyang Dairy Product Co. Ltd produced and provided the functional yogurt NY-YP901 and the control yogurt for this study.

Author information

Author notes

  1. B J Chang and S U Park: These authors contributed equally to this work.

Authors and Affiliations

  1. Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

    B J Chang, S U Park, Y S Jang & D K Chang

  2. Department of Food and Nutrition, Sookmyung Women's University, Seoul, Korea

    S H Ko, N M Joo & S I Kim

  3. Department of Animal Resource and Science, Dankook University, Cheonan, Korea

    C-H Kim

Authors
  1. B J Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S U Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Y S Jang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S H Ko
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N M Joo
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S I Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. C-H Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. D K Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D K Chang.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chang, B., Park, S., Jang, Y. et al. Effect of functional yogurt NY-YP901 in improving the trait of metabolic syndrome. Eur J Clin Nutr 65, 1250–1255 (2011). https://doi.org/10.1038/ejcn.2011.115

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ejcn.2011.115

Keywords

This article is cited by

Search

Advanced search

Quick links