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Preoperative autologous blood donation in healthy bone marrow donors contributes to pre-procedure anemia

Bone Marrow Transplantation volume 52, pages 1191–1193 (2017)Cite this article

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Preoperative autologous blood donation (PAD) boomed in popularity during the 1980s and 1990s after it was recognized that HIV and HCV could be transmitted by allogeneic blood transfusion.1 At the peak of this public health concern, the World Marrow Donor Association (WMDA) and the National Marrow Donor Program (NMDP) produced guidelines stating that all bone marrow harvest centers should collect preoperative autologous blood for transfusion back into volunteer donors during or after their harvest procedure.2, 3, 4, 5

In the past decade, with significantly reduced risk of allogeneic transfusion-transmitted disease, recognition of the risks associated with autologous transfusion, multiple landmark studies supporting restrictive transfusion thresholds, increased non-transfusion management options, and increased focus on constraining healthcare costs, there has been a marked decline in the practice of PAD.1 However, PAD among healthy bone marrow donors remains a widespread practice. To better understand the benefits and harms to our institution’s volunteer marrow donor population, we obtained Institutional Review Board permission to retrospectively review the records of volunteer bone marrow donors undergoing marrow harvest at our large academic medical center between January 2009 and December 2013 (Harvard Committee on the Use of Human Subjects, Protocol# 2014P000352).

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References

  1. Vassallo R, Goldman M, Germain M, Lozano M . BEST Collaborative. Preoperative autologous blood donation: waning indications in an era of improved blood safety. Transfus Med Rev 2015; 29: 268–275.

    Article  Google Scholar 

  2. Goldman JM . for the WMDA Executive Committee A special report-bone marrow transplants using volunteer donors-recommendations and requirements for a standardized practice throughout the world. Blood 1994; 84: 2833–2839.

    CAS  Google Scholar 

  3. Cleaver SA, Warren P, Kern M, Hurley CK, Raffoux C, Keller J et al. Donor work-up and transport of bone marrow—recommendations and requirements for a standardized practice throughout the world from the Donor Registries and Quality Assurance Working Groups of the World Marrow Donor Association (WMDA). Bone Marrow Transplant 1997; 20: 621–629.

    Article  CAS  Google Scholar 

  4. Lown RN, Philippe J, Navarro W, van Walraven SM, Philips-Johnson L, Fechter M et al. World Marrow Donor Association Clinical Working Group Committee. Unrelated adult stem cell donor medical suitability: recommendations from the World Marrow Donor Association Clinical Working Group Committee. Bone Marrow Transplant 2014; 49: 880–886.

    Article  CAS  Google Scholar 

  5. You’re a Match: a Donor’s Guide to Donation. National Marrow Donor Program. [updated June 2011; accessed 10/31/2016]. Available from https://bethematch.org/registry_members/a_possible_match/you_could_save_a_life_(pdf).aspx.

  6. Parkkali T, Juvonen E, Volin L, Partanen J, Ruutu T . Collection of autologous blood for bone marrow donation: how useful is it? Bone Marrow Transplant 2005; 35: 1035–1039.

    Article  CAS  Google Scholar 

  7. Mijovic A, Britten C, Regan F, Harrison J . Preoperative autologous blood donation for bone marrow harvests: are we wasting donors' time and blood? Transfus Med 2006; 16: 57–62.

    Article  CAS  Google Scholar 

  8. Gouëzec H, Ferré N, Hervé F, Lapart C, Leberre C, Bernard M et al Suitability of autologous blood donation before bone marrow donation. Transfus Clin Biol 2015; 22: 71–75.

    Article  Google Scholar 

  9. Kiss JE, Brambilla D, Glynn SA, Mast AE, Spencer BR, Stone M et al. National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemiology and Donor Evaluation Study–III (REDS-III). Oral iron supplementation after blood donation: a randomized clinical trial. JAMA 2015; 313: 575–583.

    Article  Google Scholar 

  10. Henry DA, Carless PA, Moxey AJ, O'Connell D, Forgie MA, Wells PS, Fergusson D . Pre-operative autologous donation for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 2002; (2): CD003602.

    Google Scholar 

  11. Carson JL, Stanworth SJ, Roubinian N, Fergusson DA, Triulzi D, Doree C et al. Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev 2016; 10: CD002042.

    PubMed  Google Scholar 

  12. Vamvakas EC . Meta-analysis of randomized controlled trials comparing the risk of postoperative infection between recipients of allogeneic and autologous blood transfusion. Vox Sang 2002; 83: 339–346.

    Article  CAS  Google Scholar 

  13. Domen RE . Adverse reactions associated with autologous blood transfusion: evaluation and incidence at a large academic hospital. Transfusion 1998; 38: 296–300.

    Article  CAS  Google Scholar 

  14. Zou S, Stramer SL, Dodd RY . Donor testing and risk: current prevalence, incidence, and residual risk of transfusion-transmissible agents in US allogeneic donations. Transfus Med Rev 2012; 26: 119–128.

    Article  Google Scholar 

  15. Etchason J, Petz L, Keeler E, Calhoun L, Kleinman S, Snider C et al. The cost effectiveness of preoperative autologous blood donations. N Engl J Med 1995; 332: 719–724.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Anesthesia and Perioperative Care, University of California, San Francisco, School of Medicine, San Francisco, CA, USA

    S P Manuel

  2. Division of Hematology Oncology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA

    T R Spitzer

  3. Department of Anesthesia, Critical Care and Pain Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA

    Y Ishizawa

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  1. S P Manuel
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  2. T R Spitzer
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  3. Y Ishizawa
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Correspondence to S P Manuel.

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Manuel, S., Spitzer, T. & Ishizawa, Y. Preoperative autologous blood donation in healthy bone marrow donors contributes to pre-procedure anemia. Bone Marrow Transplant 52, 1191–1193 (2017). https://doi.org/10.1038/bmt.2017.84

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