Abstract
Autologous haematopoietic SCT (AHSCT) is increasingly used to control severe and refractory autoimmune diseases (AD). Many patients are women of reproductive age with a potential desire for children. We present a multicentre retrospective analysis of pregnancy and childbirth in patients who underwent AHSCT for AD. The databases of the European Blood and Marrow Transplantation and University of Sao Paulo, Ribeirão Preto, Brazil were searched for female patients aged 18–50 years who had received AHSCT for AD between 1994–2011. In 324 adult female patients, 22 pregnancies were reported in 15 patients between 1997–2011. Indications for AHSCT included multiple sclerosis (n=7), systemic sclerosis (n=5), rheumatoid arthritis (n=1), juvenile idiopathic arthritis (n=1) and Takayasu disease (n=1). Of the 22 reported pregnancies, 20 followed natural conception. 15 pregnancies (68%) resulted in healthy life births, whereas 7 (32%) failed. Exacerbations of AD occurred in two patients during second pregnancies. No maternal mortality was associated with pregnancy or postpartum. There were no reports of congenital, developmental or any other disease in the children. This retrospective analysis confirms the possibility of pregnancy and childbirth following AHSCT for severe AD. The outcome of pregnancy is generally good and most led to the birth of a healthy child.
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ES, JAS and DF were the principal investigators and take primary responsibility for the paper; they had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: ES, JAS and DF. Acquisition of data: MB, DF, SHK, JAS, JM, MM, AC, JT, TM, MR, AS, MCO, BPS, RC, CC and JB recruited the patients. Drafting of the manuscript: ES, JS and DF. Statistical analysis: MB and ML. Administrative, technical or material support: EBMT.
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Snarski, E., Snowden, J., Oliveira, M. et al. Onset and outcome of pregnancy after autologous haematopoietic SCT (AHSCT) for autoimmune diseases: a retrospective study of the EBMT autoimmune diseases working party (ADWP). Bone Marrow Transplant 50, 216–220 (2015). https://doi.org/10.1038/bmt.2014.248
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DOI: https://doi.org/10.1038/bmt.2014.248
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