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Post-Transplant Events

Glutathione S-transferase T1-null seems to be associated with graft failure in hematopoietic SCT

Bone Marrow Transplantation volume 45, pages 1728–1731 (2010)Cite this article

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Abstract

Hematopoietic SCT (HSCT) from HLA-matched donors is sometimes complicated by GVHD or graft rejection, because of mismatched mHA. This study presents data suggesting the involvement of glutathione S-transferase theta-1 (GSTT1), a phase II detoxifying enzyme encoded by GSTT1, in Ab-mediated rejection of HSCT in children with congenital hemoglobinopathies (CHs). Mismatch of GSTT1, which often features a deletion polymorphism variant, can have major consequences in solid organ transplantation outcome. In liver transplantation, it has been shown to lead to de novo hepatitis, whereas in kidney transplantation, chronic allograft rejection has been documented. In this study on 18 children with CH who underwent HSCT, five cases of graft rejection occurred, all in GSTT1-null patients, four of which featured anti-GSTT1 antibodies. The data suggest that when GSTT1-null patients are transplanted with a GSTT1-positive graft, rejection due to an Ab-mediated immune response against GSTT1 displayed on transplanted stem cells may take place. Thus, it seems that detection of anti-GSTT1 antibodies in patients with a GSTT1-null genotype before transplantation may be predictive of graft rejection in the event of a GSTT1-positive donor.

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Acknowledgements

The authors thank Mrs Osnat Gidoni, MSc, for her technical help. This study was funded in part by a grant from the Israel Cancer Association in the name of Israel Jacob and Lila Halter (number 20090070).

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Authors and Affiliations

  1. Pediatric Hemato-Oncology and Bone Marrow Transplant Department, Meyer Children's Hospital, Rambam Health Care Campus, Haifa, Israel

    R Elhasid

  2. B. Rappaport Faculty of Medicine, Technion-Institute of Technology, Haifa, Israel

    R Elhasid, N Krivoy, J M Rowe & E Sprecher

  3. Clinical Pharmacology Institute, Rambam Health Care Campus, Haifa, Israel

    N Krivoy

  4. Hematology Institute Rambam Health Care Campus, Haifa, Israel

    J M Rowe

  5. Center for Translational Genetics, B. Rappaport Institute for Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology and Rambam Health Care Campus, Haifa, Israel

    E Sprecher & E Efrati

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  1. R Elhasid
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Correspondence to R Elhasid.

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Elhasid, R., Krivoy, N., Rowe, J. et al. Glutathione S-transferase T1-null seems to be associated with graft failure in hematopoietic SCT. Bone Marrow Transplant 45, 1728–1731 (2010). https://doi.org/10.1038/bmt.2010.61

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