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Inhibition of tumorigenesis by intratumoral delivery of the circadian gene mPer2 in C57BL/6 mice

Cancer Gene Therapy volume 14, pages 815–818 (2007)Cite this article

Abstract

Biological clocks are intrinsic time-keeping systems that regulate behavior and physiological functions in most living organisms. Previous works suggested a possible link between the endogenous circadian clock and cell cycle regulation. The mammalian Period-2 gene (mPer2), an important component of the circadian clock mechanism, is recently demonstrated to play an important role in repressing tumor growth. In this study, we found that polyethylenimine-mediated intratumoral Per2 gene delivery had significant antitumor effects in C57BL/6 mice transplanted with Lewis lung carcinoma. Our data illustrated that the Per2 gene delivery inhibited PCNA expression and induced apoptosis. Our results support the emerging role of the circadian clock in critical aspects of tumorigenesis. These findings underscore the potential use of Per2 gene delivery as a novel therapeutic intervention for the treatment of malignant tumors.

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GenBank/EMBL/DDBJ

Abbreviations

mPer2 :

mammalian Period 2

LLC:

Lewis lung carcinoma

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Acknowledgements

This study was supported by National Nature Science Foundation of China (No. 30470623 for ZW, No. 30470684 for CW), the Chinese Medical Board of New York, USA (ZW) and the NIH NS047014 for JM D.

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Authors and Affiliations

  1. Laboratory of Molecular Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

    H Hua

  2. Health Ministry Key Laboratory of Chronobiology, State Key Laboratory of Biotherapy, West China Medical Center, Sichuan University, Chengdu, China

    H Hua, Y Wang, C Wan, Y Liu, B Zhu & Z Wang

  3. Department of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, USA

    X Wang & J M Ding

Authors
  1. H Hua
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  2. Y Wang
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  3. C Wan
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  4. Y Liu
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  5. B Zhu
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  6. X Wang
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  7. Z Wang
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  8. J M Ding
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Correspondence to Z Wang.

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Hua, H., Wang, Y., Wan, C. et al. Inhibition of tumorigenesis by intratumoral delivery of the circadian gene mPer2 in C57BL/6 mice. Cancer Gene Ther 14, 815–818 (2007). https://doi.org/10.1038/sj.cgt.7701061

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  • DOI: https://doi.org/10.1038/sj.cgt.7701061

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