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Renin–angiotensin system gene polymorphisms: relationship with blood pressure and microalbuminuria in telmisartan-treated hypertensive patients

The Pharmacogenomics Journal volume 5, pages 14–20 (2005)Cite this article

Abstract

This study analyzed the relationship between four renin–angiotensin system (RAS) gene polymorphisms and the response to blood pressure lowering and development of microalbuminuria in 206 patients with essential hypertension treated once daily for 12 months with telmisartan 80 mg. Seated cuff blood pressure and urinary albumin excretion (UAE) were measured throughout the study. Patients were screened for the presence of the A-6G variant of the angiotensinogen gene, angiotensin-converting enzyme insertion/deletion polymorphism, and the A1166C and C573T polymorphisms of the angiotensin II type 1 receptor gene. No significant association was found between the presence of any gene polymorphism and the reduction of blood or UAE following telmisartan treatment. The results indicate that these RAS gene polymorphisms do not affect the antihypertensive activity and renoprotection in mild-to-moderate hypertensive patients treated with telmisartan.

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Acknowledgements

The study was supported by a Research Grant of Glaxo, Spain.

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Author notes

  1. J Redon, M Luque-Otero, N Martell and F J Chaves: For list of researchers of the POLPRI study see Appendix A1.

Authors and Affiliations

  1. Hypertension Clinic, Hospital Clinico, University of Valencia, Spain

    J Redon & F J Chaves

  2. Hypertensión Unit, Hospital Clínico Universitario San Carlos, Madrid, Spain

    M Luque-Otero & N Martell

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  1. J Redon
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  2. M Luque-Otero
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  3. N Martell
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  4. F J Chaves
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on behalf of the POLPRI investigators

Corresponding author

Correspondence to J Redon.

Appendix A1

Appendix A1

List of researchers of the POLPRI study J Redon, V Giner, Hospital Clínico Universitario, Valencia; M Luque, N Martel, Hospital Clinico San Carlos, Madrid; C Fernandez-Torres, Hospital Virgen de las Nieves, Granada; S Najaty, Hospital Clínico Universitario, Valladolid; J Olivan, Hospital Virgen de la Macarena, Sevilla; A Martin-Hidalgo, Hospital General Universitario, Elche; P Cia, Hospital Clínico Universitario, Zaragoza; MA Courel, Hospital Xeral, Vigo; J Plana, Hospital San Camil, Barcelona; J Villatoro, Hospital General, Castellon; C Fernandez, Ciudad Sanitaria Virgen del Rocio, Sevilla; J Poblador, Hospital General, Mallorca; P Aranda, Hospital Regional Carlos Haya, Málaga; J Abellan, Centro de Salud, Murcia; J Viladoms, Hospital de Mollet de Vallés, Barcelona; A Martinez-Amenos, Hospital Principes de España, Hospitalet del Llobregat; A Liebana, Hospital Ciudad de Jaén, Jaen; A Salcedo, Hospital de Galdácano, Bilbao.

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Redon, J., Luque-Otero, M., Martell, N. et al. Renin–angiotensin system gene polymorphisms: relationship with blood pressure and microalbuminuria in telmisartan-treated hypertensive patients. Pharmacogenomics J 5, 14–20 (2005). https://doi.org/10.1038/sj.tpj.6500280

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