Abstract
In the present review activities of two bacterial toxins, Clostridium botulinum exoenzyme C3 and Escherichia coli CNF1, both acting on the GTP-binding protein Rho are analyzed. Proteins belonging to the Rho family regulate the actin cytoskeleton and act as molecular switches in a number of signal transduction pathways. C3 and CNF1 have opposite effects on Rho thus representing useful tools for studies on cell division, cell differentiation and apoptosis.
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Fiorentini, C., Gauthier, M., Donelli, G. et al. Bacterial toxins and the Rho GTP-binding protein: what microbes teach us about cell regulation. Cell Death Differ 5, 720–728 (1998). https://doi.org/10.1038/sj.cdd.4400412
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DOI: https://doi.org/10.1038/sj.cdd.4400412
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