Abstract
Nitrogen fixation is a symbiotic process initiated by chemical signals from legumes that are recognized by soil bacteria. Here we show that some endocrine-disrupting chemicals (EDCs)1,2,3, so called because of their effect on hormone-signalling pathways in animal cells, also interfere with the symbiotic signalling that leads to nitrogen fixation. Our results raise the possibility that these phytochemically activated pathways may have features in common with hormonal signalling in vertebrates, thereby extending the biological and ecological impact of EDCs.
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References
Tham, D. M., Gardner, C. D. & Haskell, W. L. J. Clin. Endocrinol. Metab. 83, 2223–2235 (1998).
Collins-Burow, B. M. et al. Nutr. Cancer 38, 229–244 (2000).
McLachlan, J. A. Endocrinol. Rev. 22, 319–341 (2001).
Schultze, M. & Kondorosi, A. Annu. Rev. Genet. 32, 33–57 (1998).
Peters, N. K., Frost, J. W. & Long, S. R. Science 233, 977–980 (1986).
Djordjevic, M. A. et al. EMBO J. 6, 1173–1179 (1987).
Firmin, J. L. et al. Nature 324, 90–93 (1986).
Gyorgypal, Z. & Kondorosi, A. Mol. Gen. Genet. 226, 337–340 (1991).
Mulligan, J. T. & Long, S. R. Proc. Natl Acad. Sci. USA 82, 6609–6613 (1985).
Peters, N. K. & Long, S. R. Plant Physiol. 88, 396–400 (1988).
Redmond, J. W. et al. Nature 323, 632–635 (1986).
Gage, D. J., Bobo, T. & Long, S. R. J. Bacteriol. 178, 7159–7166 (1996).
Baker, M. E. Adv. Exp. Med. Biol. 439, 249–276 (1998).
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Fox, J., Starcevic, M., Kow, K. et al. Endocrine disrupters and flavonoid signalling. Nature 413, 128–129 (2001). https://doi.org/10.1038/35093163
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DOI: https://doi.org/10.1038/35093163
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