Abstract
We have introduced a cloned Ekα gene into embryos of mice incapable of expressing their endogenous Eα genes. The transcription of Ekα was accurate and tissue-specific in the resulting transgenic lines and, in macrophages, Ekα transcription could be induced by γ-interferon. The injected gene conferred on the genetically deficient host strain the ability to mount an immune response to a synthetic polymer.
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Le Meur, M., Gerlinger, P., Benoist, C. et al. Correcting an immune-response deficiency by creating Eα gene transgenic mice. Nature 316, 38–42 (1985). https://doi.org/10.1038/316038a0
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DOI: https://doi.org/10.1038/316038a0
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