Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review Article
  • Published:

Variety in the level of gene control in eukaryotic cells

Nature volume 297, pages 365–371 (1982)Cite this article

Abstract

In light of present progress in the understanding of how messenger RNA is constructed in eukaryotic cells, the levels of gene control are discussed. Transcriptional control, assessed by the rate of synthesis of specific nuclear RNA, is strongly indicated to be the most frequent level of control. Definition of eukaryotic transcription units as simple (encoding one protein} and complex (encoding two or more proteins) affords a framework in which to discuss control at the level of RNA processing for which several examples also are known. Finally, differential stability of cytoplasmic mRNAs and differential translation, both well established, are briefly described.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Weber, J., Jelinek, W. & Darnell, J. E. Cell 10, 611–616 (1977).

    CAS  PubMed  Google Scholar 

  2. Goldberg, S., Schwartz, H. & Darnell, J. E. Cell 10, 617–621 (1977).

    CAS  PubMed  Google Scholar 

  3. Goldberg, S., Weber, J. & Darnell, J. E. Proc. natn. Acad. Sci. U.S.A. 74, 4520–4523 (1977).

    ADS  CAS  Google Scholar 

  4. Evans, R. M. et al. Cell 12, 733–739 (1977).

    CAS  PubMed  Google Scholar 

  5. Hofer, E. & Darnell, J. E. Cell 23, 585–593 (1981).

    CAS  PubMed  Google Scholar 

  6. Darnell, J. E. Prog. Nucleic Acid Res. molec. Biol. 22, 327–353 (1979).

    CAS  Google Scholar 

  7. Ziff, E. B. Nature 287, 491–499 (1980).

    ADS  CAS  PubMed  Google Scholar 

  8. Shatkin, A. J. Cell 9, 645–653 (1976).

    CAS  PubMed  Google Scholar 

  9. Brawerman, G. CRC Rev. Biochem., 1–38 (1981).

  10. Jelinek, W. et al. J. molec. Biol. 75, 515–532 (1973).

    CAS  PubMed  Google Scholar 

  11. Nevins, J. R. & Darnell, J. E. Cell 15, 1477–1493 (1978).

    CAS  PubMed  Google Scholar 

  12. Fraser, N. W., Nevins, J. R., Ziff, E. & Darnell, J. E. J. molec. Biol. 129, 643–656 (1979).

    CAS  PubMed  Google Scholar 

  13. Nevins, J. R., Blanchard, J.-M. & Darnell, J. F. J. molec. Biol. 144, 377–386 (1980).

    CAS  PubMed  Google Scholar 

  14. Ford, J. P. & Hsu, M. T. J. Virol. 28, 795–801 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  15. Gilbert, W. Nature 271, 501 (1978).

    ADS  CAS  PubMed  Google Scholar 

  16. Berget, S. M., Moore, C. & Sharp, P. A. Proc. natn. Acad. Sci. U.S.A. 74, 3171–3175 (1977).

    ADS  CAS  Google Scholar 

  17. Chow, L. T., Gelinas, R. E., Broker, T. R. & Roberts, R. J. Cell 12, 1–8 (1977).

    Article  CAS  PubMed  Google Scholar 

  18. Klessig, D. F. Cell 12, 9–23 (1977).

    Article  CAS  PubMed  Google Scholar 

  19. Scherrer, K. & Marcaud, L. J. cell. Physiol. 72, Suppl. 1, 181–212 (1968).

    CAS  Google Scholar 

  20. Darnell, J. E., Jelinek, W. & Molloy, G. Science 181, 1215–1222 (1973).

    ADS  CAS  PubMed  Google Scholar 

  21. Korn, L. J. & Gurdon, J. B. Nature 289, 461–465 (1981).

    ADS  CAS  PubMed  Google Scholar 

  22. Weisbrod, S. Nature 297, 289–295 (1982).

    ADS  CAS  PubMed  Google Scholar 

  23. Roeder, R. in RNA Polymerases (eds Losick, R. & Chamberlin, M.) 285–329 (Cold 43. Spring Harbor Laboratory, New York, 1976).

    Google Scholar 

  24. Corden, J. et al. Science 209, 1406–1414 (1980).

    ADS  CAS  PubMed  Google Scholar 

  25. Ziff, E. & Evans, R. M. Cell 15, 1463–1475 (1978).

    CAS  PubMed  Google Scholar 

  26. Weil, P. A., Luse, D. S., Segall, J. & Roeder, R. G. Cell 18, 469–484 (1979).

    CAS  PubMed  Google Scholar 

  27. Baker, C. & Ziff, E. J. molec. Biol. 149, 189–221 (1981).

    CAS  PubMed  Google Scholar 

  28. Goldberg, M. thesis, Stanford Univ. (1978).

  29. Benoist, C. & Chambon, P. Nature 290, 304–310 (1981).

    ADS  CAS  PubMed  Google Scholar 

  30. Ucker, D. S., Ross, S. R. & Yamamoto, K. R. Cell 27, 257–266 (1981).

    CAS  PubMed  Google Scholar 

  31. Struhl, L. & Davis, R. J. molec. Biol. 52, 553–568 (1970).

    Google Scholar 

  32. Struhl, K. J. molec. Biol. 52, 569–576 (1970).

    Google Scholar 

  33. McKnight, S. L., Gavis, E. R., Kingsbury, R. & Axel, R. Cell 25, 385–398 (1981).

    CAS  PubMed  Google Scholar 

  34. Mellon, P., Parker, V., Gluzman, Y. & Maniatis, T. Cell 27, 279–288 (1981).

    CAS  PubMed  Google Scholar 

  35. Fraser, N. W., Sehgal, P. B. & Darnell, J. F. Proc. natn. Acad. Sci. U.S.A. 76, 2571–2575 (1979).

    ADS  CAS  Google Scholar 

  36. Salditt-Georgieff, M., Harpold, M., Chen-Kiang, S. & Darnell, J. E. Cell 19, 69–78 (1980).

    CAS  PubMed  Google Scholar 

  37. Jacob, F. & Monod, J. J. molec. Biol. 3, 318–356 (1961).

    CAS  PubMed  Google Scholar 

  38. Miller, J. H. & Reznikoff, W. W. (eds) The Operon (Cold Spring Harbor Laboratory, New York, 1978).

  39. Yanofsky, C. Nature 289, 751–759 (1981).

    ADS  CAS  PubMed  Google Scholar 

  40. Hayashi, M., Spiegelman, S., Franklin, N. C. & Lauria, S. E. Proc. natn. Acad. Sci. U.S.A. 49, 729–736 (1963).

    ADS  CAS  Google Scholar 

  41. Bertrand, K., Squires, C. & Yanofsky, C. J. molec. Biol. 103, 319–337 (1976).

    CAS  PubMed  Google Scholar 

  42. Lozeron, H. A., Dahlberg, J. E. & Szybalski, W. Virology 71, 262–277 (1976).

    CAS  PubMed  Google Scholar 

  43. Harpold, M. M., Evans, R. M., Salditt-Georgieff, M. & Darnell, J. E. Cell 17, 1025–1035 (1979).

    CAS  PubMed  Google Scholar 

  44. Salditt-Georgieff, M. & Darnell, J. E. Molec. cell. Biol. 3 (in the press).

  45. Cox, R. F. Cell 7, 455–465 (1976).

    CAS  PubMed  Google Scholar 

  46. Wall, R., Philipson, L. & Darnell, J. E. Virology 50, 27–34 (1972).

    CAS  PubMed  Google Scholar 

  47. Weber, J. thesis, Rockefeller Univ. (1979).

  48. Derman, E. et al. Cell 23, 731–739 (1981).

    CAS  PubMed  Google Scholar 

  49. Lowenhaupt, K., Trent, C. & Lingrel, J. B. Devl Biol. 63, 441–454 (1978).

    CAS  Google Scholar 

  50. Nevins, J. R., Ginsberg, H. W., Blanchard, J. M., Wilson, M. C. & Darnell, J. E. J. Virol. 32, 727–733 (1979).

    CAS  PubMed  PubMed Central  Google Scholar 

  51. Carter, T. H. & Blanton, R. J. Virol. 25, 664–674 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  52. Pettersson, U. & Matthews, M. B. Cell 12, 741–750 (1977).

    CAS  PubMed  Google Scholar 

  53. Wilson, M. C., Fraser, N. W. & Darnell, J. E. Virology 94, 178–184 (1979).

    Google Scholar 

  54. Fraser, N. W. & Ziff, E. J. molec. Biol. 155 (in the press).

  55. Jones, N. & Shenk, T. Proc. natn. Acad. Sci. U.S.A. 76, 3665–3669 (1979).

    ADS  CAS  Google Scholar 

  56. Harrison, T., Graham, F. & Williams, J. Virology 77, 319–329 (1977).

    CAS  PubMed  Google Scholar 

  57. Berk, A. J., Lee, F., Harrison, T., Williams, J. & Sharp, P. A. Cell 17, 935–944 (1979).

    CAS  PubMed  Google Scholar 

  58. Nevins, J. R. Cell 26, 213–220 (1981).

    CAS  PubMed  Google Scholar 

  59. Shenk, T., Jones, N., Colby, W. & Fowlkes, D. Cold Spring Harb. Symp. quant. Biol. 44, 367–375 (1979).

    Google Scholar 

  60. Chow, L. T., Broker, T. R. & Lewis, J. B. J. molec. Biol. 134, 265–303 (1979).

    CAS  PubMed  Google Scholar 

  61. Shaw, A. R. & Ziff, E. Cell 22, 905–916 (1980).

    CAS  PubMed  Google Scholar 

  62. Nevins, J. R. & Wilson, M. C. Nature 290, 113–118 (1981).

    ADS  CAS  PubMed  Google Scholar 

  63. Akusjarvi, G. & Persson, H. Nature 292, 420–426 (1981).

    ADS  CAS  PubMed  Google Scholar 

  64. Wilson, M. C. & Darnell, J. E. J. molec. Biol. 148, 231–251 (1981).

    CAS  PubMed  Google Scholar 

  65. Ziff, E. & Fraser, N. W. J. Virol. 25, 897–906 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  66. McGrogan, M. & Raskas, H. J. Proc. natn. Acad. Sci. U.S.A. 75, 625–629 (1978).

    ADS  CAS  Google Scholar 

  67. Nevins, J. & Darnell, J. E. J. Virol. 25, 811–823 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  68. Nevins, J. R. & Jensen-Winkler, J. Proc. natn. Acad. Sci. U.S.A. 77, 1893–1897 (1980).

    ADS  CAS  Google Scholar 

  69. Acheson, N. H. in Molecular Biology of Tumor Viruses 2nd edn, Pt 2 (ed. Tooze, J.) (Cold Spring Harbor Laboratory, New York, 1980).

    Google Scholar 

  70. Alwine, J. C., Kemp, D. J. & Stark, G. R. Proc. natn. Acad. Sci. U.S.A. 74, 5350–5354 (1977).

    ADS  CAS  Google Scholar 

  71. Rio, D., Robbins, A., Meyers, R. & Tjian, R. Proc. natn. Acad. Sci. U.S.A. 77, 5706–5710 (1980).

    ADS  CAS  Google Scholar 

  72. Myers, R. M., Rio, D. C., Robbins, A. K. & Tjian, R. Cell 25, 373–384 (1981).

    CAS  PubMed  Google Scholar 

  73. Gutai, M. W. & Nathans, D. J. molec. Biol. 126, 259–274 (1978).

    CAS  PubMed  Google Scholar 

  74. Swaneck, G. E., Nordstrom, J. L., Krenzalee, F., Tsai, M.-J. & O'Malley, B. W. Proc. natn. Acad. Sci. U.S.A. 76, 1049–1053 (1979).

    ADS  CAS  Google Scholar 

  75. McKnight, G. S. & Palmiter, R. D. J. biol. Chem. 254, 9050–9058 (1978).

    Google Scholar 

  76. Tsai, S. et al. Biochemistry 17, 5733–5780 (1979).

    Google Scholar 

  77. Goldberger, R. in The Role of RNA in Development and Reproduction (eds Niu, M. & Chuang, H. H.) 215–231 (Science, Beijing, 1981).

    Google Scholar 

  78. Wiskocil, R. et al. Proc. natn. Acad. Sci. U.S.A. 77, 4474–4478 (1980).

    ADS  CAS  Google Scholar 

  79. Groudine, M., Peretz, M. & Weintraub, H. Molec. cell. Biol. 1, 281–288 (1981).

    CAS  PubMed  PubMed Central  Google Scholar 

  80. Groudine, M. & Weintraub, H. Cell 24, 333–334 (1981).

    PubMed  Google Scholar 

  81. Finlayson, J. S., Asofsky, R., Potter, M. & Runner, C. Science 149, 981–982 (1965).

    ADS  CAS  PubMed  Google Scholar 

  82. Derman, E. Proc. natn. Acad. Sci. U.S.A. 78, 5425–5429 (1981).

    ADS  CAS  Google Scholar 

  83. Hagenbuchle, O. et al. Nature 289, 643–646 (1981).

    ADS  CAS  PubMed  Google Scholar 

  84. Young, R. A., Hagenbuchle, O. & Schibler, U. Cell 23, 451–458 (1981).

    CAS  PubMed  Google Scholar 

  85. Cold Spring Harb. Symp. quant. Biol. 46 (1981).

  86. Babich, A., Nevins, J. R. & Darnell, J. E. Nature 287, 246–248 (1980).

    ADS  CAS  PubMed  Google Scholar 

  87. Contreras, R. & Fiers, W. Nucleic Acids Res. 9, 215–236 (1981).

    CAS  PubMed  PubMed Central  Google Scholar 

  88. Venkatesan, S. & Moss, B. J. J. biol. Chem. 255, 2835–2842 (1980).

    CAS  PubMed  Google Scholar 

  89. Venkatesan, S., Gershowitz, H. & Moss, B. J. J. biol. Chem. 255, 2829–2834 (1980).

    CAS  PubMed  Google Scholar 

  90. Adesnik, M. & Darnell, J. E. J. molec. Biol. 67, 397–406 (1972).

    CAS  PubMed  Google Scholar 

  91. Hentschel, C. C. & Birnstiel, M. L. Cell 25, 30–313 (1981).

    Google Scholar 

  92. Salditt-Georgieff, M., Harpold, M., Wilson, M. & Darnell, J. E. Molec. cell. Biol. 1, 179–187 (1981).

    CAS  PubMed  PubMed Central  Google Scholar 

  93. Harpold, M., Wilson, M. & Darnell, J. E. Molec. cell. Biol. 1, 188–198 (1981).

    CAS  PubMed  PubMed Central  Google Scholar 

  94. Minty, A. J. & Gros, F. J. molec. Biol. 139, 61–83 (1980).

    CAS  PubMed  Google Scholar 

  95. Reddy, V. B. et al. Science 200, 494–502 (1978).

    ADS  CAS  PubMed  Google Scholar 

  96. Legon, S., Flavell, A., Cowie, A. & Kamen, R. Cell 16, 373–388 (1979).

    CAS  PubMed  Google Scholar 

  97. Acheson, N. H. Proc. natn. Acad. Sci. U.S.A. 75, 4754–4758 (1978).

    ADS  CAS  Google Scholar 

  98. Rogers, J. et al. Cell 20, 303–312 (1980).

    CAS  PubMed  Google Scholar 

  99. Alt, F. W. et al. Cell 20, 293–301 (1980).

    CAS  PubMed  Google Scholar 

  100. Maki, R. et al. Cell 24, 353–365 (1981).

    CAS  PubMed  Google Scholar 

  101. Proudfoot, N. J. & Brownlee, G. G. Nature 263, 211–214 (1976).

    ADS  CAS  PubMed  Google Scholar 

  102. Fitzgerald, M. & Shenk, T. Cell 24, 251–260 (1981).

    CAS  PubMed  Google Scholar 

  103. Lai, C.-J., Dhar, R. & Khoury, G. Cell 14, 971–982 (1978).

    CAS  PubMed  Google Scholar 

  104. Tilghman, S. M., Curtis, P. J., Tiemeier, D. C., Leder, P. & Weissman, C. Proc. natn. Acad. Sci. U.S.A. 75, 1309–1313 (1978).

    ADS  CAS  Google Scholar 

  105. Roop, D. R. et al. Cell 15, 671–685 (1978).

    CAS  PubMed  Google Scholar 

  106. Zeevi, M., Nevins, J. R. & Darnell, J. E. Cell 26, 39–46 (1981).

    CAS  PubMed  Google Scholar 

  107. Zeevi, M., Nevins, J. R. & Darnell, J. E. Molec. cell. Biol. 3 (in the press).

  108. Nudel, U. et al. Eur. J. Biochem. 64, 115–125 (1976).

    CAS  PubMed  Google Scholar 

  109. Huez, G., Bruck, C. & Cleuter, Y. Proc. natn. Acad. Sci. U.S.A. 78, 908–911 (1981).

    ADS  CAS  Google Scholar 

  110. Salditt-Georgieff, M. et al. Cell 7, 227–237 (1976).

    CAS  PubMed  Google Scholar 

  111. Sommer, S. et al. Nucleic Acids Res. 3, 749–766 (1976).

    CAS  PubMed  PubMed Central  Google Scholar 

  112. Chen-Kiang, S., Nevins, J. R. & Darnell, J. E. J. molec. Biol. 135, 733–752 (1979).

    CAS  PubMed  Google Scholar 

  113. Alestrom, P. G. et al. Cell 19, 671–681 (1980).

    CAS  PubMed  Google Scholar 

  114. Nagata, S., Mantei, N. & Weissman, C. Nature 287, 401–408 (1980).

    ADS  CAS  PubMed  Google Scholar 

  115. Konkel, D. A., Tilghman, S. M. & Leder, P. Cell 15, 1125–1132 (1978).

    CAS  PubMed  Google Scholar 

  116. Nishioka, Y. & Leder, P. Cell 18, 875–882 (1979).

    CAS  PubMed  Google Scholar 

  117. Kitchingman, G., Lai, S. & Westphal, H. Proc. natn. Acad. Sci. U.S.A. 74, 4392–4395 (1977).

    ADS  CAS  Google Scholar 

  118. Fiers, W. et al. Nature 273, 113–120 (1978).

    ADS  CAS  PubMed  Google Scholar 

  119. Soeda, E., Arrand, J. R., Smolar, N., Walsh, J. E. & Griffin, B. E. Nature 283, 445–453 (1980).

    ADS  CAS  PubMed  Google Scholar 

  120. Berk, A. J. & Sharp, P. A. Cell 14, 695–711 (1978).

    CAS  PubMed  Google Scholar 

  121. Cold Spring Harb. Symp. quant. Biol. 44, Pt 2 (1979).

  122. Stillman, B. W., Lewis, J. B., Chow, L. T., Matthews, M. B. & Smart, J. E. Cell 23, 497–508 (1981).

    CAS  PubMed  Google Scholar 

  123. Soeiro, R., Vaughn, M. H., Warner, J. R. & Darnell, J. E. J. Cell Biol. 39, 112–118 (1968).

    CAS  PubMed  PubMed Central  Google Scholar 

  124. Lewin, B. (ed.) in Gene Expression 2nd edn, 748 (Wiley-Interscience, New York, 1980).

  125. Ventateson, S., Nakazato, H., Kopp, D. W. & Edmonds, M. Nucleic Acids Res. 6, 1097–1110 (1979).

    Google Scholar 

  126. Davidson, E. H. & Britten, R. J. Science 204, 1052–1059 (1979).

    ADS  CAS  PubMed  Google Scholar 

  127. Guyette, W. A., Matuski, R. J. & Rosen, J. M. Cell 17, 1013–1023 (1979).

    CAS  PubMed  Google Scholar 

  128. Greenberg, J. R. Nature 240, 102–104 (1972).

    ADS  CAS  PubMed  Google Scholar 

  129. Palmiter, R. J. biol. Chem. 248, 8260 (1973).

    CAS  PubMed  Google Scholar 

  130. Spector, D. J., McGrogan, M. & Raskas, H. J. J. molec. Biol. 126, 395–414 (1978).

    CAS  PubMed  Google Scholar 

  131. Aviv, H., Volloch, Z., Bastos, R. & Levy, S. Cell 84, 495–503 (1976).

    Google Scholar 

  132. Bastos, R. N., Volloch, Z. & Aviv, A. J. molec. Biol. 110, 191–203 (1977).

    CAS  PubMed  Google Scholar 

  133. Volloch, V. & Housman, D. in Organization and Expression of Globin Genes (eds Stamatoyannopoulos, G. & Nienhaus, A. W.) 251–268 (Liss, New York, 1981).

    Google Scholar 

  134. Chung, S., Landfear, S. M., Blumberg, D. D., Cohen, N. S. & Lodish, H. F. Cell 24, 785–797 (1981).

    CAS  PubMed  Google Scholar 

  135. Brandhoest, B. P. Devl Biol. 52, 310–317 (1976).

    Google Scholar 

  136. Rosenthal, E., Hunt, T. & Roderman, J. V. Cell 20, 487–494 (1980).

    CAS  PubMed  Google Scholar 

  137. McCormick, W. & Penman, S. J. molec. Biol. 39, 315–333 (1969).

    CAS  PubMed  Google Scholar 

  138. Kelley, P. M. & Schlessinger, M. J. Cell 15, 1277–1286 (1978).

    CAS  PubMed  Google Scholar 

  139. Storti, R. V., Scott, M. P., Rich, A. & Pardue, M. L. Cell 22, 825–834 (1980).

    CAS  PubMed  Google Scholar 

  140. Fan, H. & Penman, S. J. J. molec. Biol. 50, 665–670 (1970).

    Google Scholar 

  141. Trachsel, H. et al. Proc. natn. Acad. Sci. U.S.A. 77, 770–774 (1980).

    ADS  CAS  Google Scholar 

  142. Skup, D., Zarbl, H. & Millward, S. J. molec. Biol. 151, 35–56 (1981).

    CAS  PubMed  Google Scholar 

  143. Fernandez-Munoz, R. & Darnell, J. E. J. Virol. 18, 719–726 (1976).

    CAS  PubMed  PubMed Central  Google Scholar 

  144. Heywood, S. M., Kennedy, D. S. & Bester, A. J. Proc. natn. Acad. Sci. U.S.A. 71, 2428–2431 (1974).

    ADS  CAS  Google Scholar 

  145. Roberts, J. L. & Herbert, E. Proc. natn. Acad. Sci. U.S.A. 74, 4826–4830, 5300–5304 (1977).

    ADS  CAS  Google Scholar 

  146. Mains, R. E. & Epper, B. A. J. biol. Chem. 251, 4115–4120 (1976).

    CAS  PubMed  Google Scholar 

  147. Bach, M.-L., Lacroute, F. & Botstein, D. Proc. natn. Acad. Sci. U.S.A. 76, 386–390 (1979).

    ADS  CAS  Google Scholar 

  148. Klar, A. J. S., Strathern, J. N., Broach, J. R. & Hicks, J. B. Nature 289, 239–244 (1981).

    ADS  CAS  PubMed  Google Scholar 

  149. Broach, J. R. J. molec. Biol. 131, 41–53 (1979).

    CAS  PubMed  Google Scholar 

  150. Hutchison, H. T., Hartwell, L. H. & McLaughlin, C. S. J. Bact. 99, 807–814 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  151. Hofer, E., Hofer-Warbinek, R. & Darnell, J. E. Jr Cell (in the press).

  152. Carlson, M. & Botstein, D. Cell 28, 145–154 (1982).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Rockefeller University, New York, New York, 10021, USA

    James E. Darnell Jr

Authors
  1. James E. Darnell Jr
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Darnell, J. Variety in the level of gene control in eukaryotic cells. Nature 297, 365–371 (1982). https://doi.org/10.1038/297365a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/297365a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing