Abstract
The MLL gene, located on chromosome band 11q23 is fused to different partner genes as a result of various chromosomal translocations in hematopoietic malignancies. A t(1;11) (q21;q23) resulting in a MLL-AF1q fusion gene has previously been reported. Cytogenetic studies on six cases are reported, including one three-way translocation. FISH analysis using a YAC encompassing the MLL gene and a YAC encompassing the AF1q locus showed splitting in three cases and two patients, respectively. PCR analysis of two cases confirmed that AF1q is specifically associated with t(1;11)(q21;q23). The MLL-AF1q fusion mRNA was similar to that previously described in one case and involved MLL exon 7 in the other. This study confirms the specific involvement of AF1q in t(1;11) (q21;q23)-positive acute leukemia with monocytic involvement.
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Coniat, ML., Salomon-Nguyen, F., Hillion, J. et al. MLL-AF1q fusion resulting from t(1;11) in acute leukemia. Leukemia 13, 302–306 (1999). https://doi.org/10.1038/sj.leu.2401299
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DOI: https://doi.org/10.1038/sj.leu.2401299
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