Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Formation of Antibiotics

Abstract

Antibiotics could owe their origin to detoxication of a metabolite that is detrimental to the culture producing the antibiotic.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Khan, A. W., Bhaduri, A. P., Gupta, C. M., and Dhar, M. M., Indian J. Biochem., 6, 220 (1969).

    CAS  PubMed  Google Scholar 

  2. Arif, A. J., Singh, C., Bhaduri, A. P., Gupta, C. M., Khan, A. W., and Dhar, M. M., Indian J. Biochem., 7, 193 (1970).

    CAS  PubMed  Google Scholar 

  3. Tolman, R. L., Robins, R. K., and Townsend, L. B., J. Amer. Chem. Soc., 91, 2102 (1969).

    Article  CAS  Google Scholar 

  4. Nakamura, G., J. Antibiotics, 14 A, 94 (1961).

    Google Scholar 

  5. McCarthy, J. R., Robins, R. K., and Robins, M. J., J. Amer. Chem. Soc., 90, 4993 (1968).

    Article  CAS  Google Scholar 

  6. Guarino, A. J., and Kredrich, N. M., Biochim. Biophys. Acta, 68, 317 (1963).

    Article  CAS  Google Scholar 

  7. Kaczka, E. A., Dulney, E. L., Gitterman, C. D., Woodruff, H. B., and Folkers, K., Biochem. Biophys. Res. Commun., 14, 452 (1964).

    Article  CAS  Google Scholar 

  8. Morton, G. O., Lancaster, J. E., Van Lear, G. E., Fulmer, W., and Meyer, W. E., J. Amer. Chem. Soc., 91, 1535 (1969).

    Article  CAS  Google Scholar 

  9. Kredrich, N. M., and Guarino, A. J., J. Biol. Chem., 236, 3300 (1961).

    Google Scholar 

  10. Baker, B. R., Schaub, R. E., Joseph, J. P., and Williams, J. H., J. Amer. Chem. Soc., 77, 12 (1955).

    Article  CAS  Google Scholar 

  11. Fox, J. J., Kuwada, Y., Watanabe, K. A., Ueda, T., and Whipple, E. B., Antimicrobiol Agents and Chemotherapy, 518 (1964).

    Google Scholar 

  12. Otake, N., Takeuchi, S., Endo, T., and Yonehara, H., Tetrahedron Lett., 1405 (1965).

  13. Fox, J. J., and Watanabe, K. A., Tetrahedron Lett., 897 (1966).

  14. Haskell, T. H., J. Amer. Chem. Soc., 80, 747 (1958).

    Article  CAS  Google Scholar 

  15. Koyama, G., Maeda, K., and Umezawa, H., Tetrahedron Lett., 597 (1966).

  16. Darnall, K. R., Townsend, L. B., and Robins, R. K., Proc. US Nat. Acad. Sci., 57, 548 (1967).

    Article  ADS  CAS  Google Scholar 

  17. Streighthoff, F. J., Nelson, J. A., Cline, J. C., Gerzon, K., Hoehn, M., Williams, R. H., Gorman, M., and Delong, D. C., Ninth Conference of Antimicrobial Agents and Chemotherapy, Abstract No. 18 (Washington DC, 1969).

    Google Scholar 

  18. Haneishi, T., Nomura, M., Okazaki, T., Naito, A., Seki, I., Arai, M., Hata, R., and Tamura, C., Meeting of Japanese Antibiotic Research Association, Tokyo, July 1970.

  19. Sensi, P., Maggi, N., Furesz, S., and Maffii, G., Antimicrobial Agents and Chemotherapy, 699 (1967).

    Google Scholar 

  20. Celmer, W. D., J. Amer. Chem. Soc., 88, 5028 (1966).

    Article  CAS  Google Scholar 

  21. Martin, J. R., and Rosenbrook, W., Biochemistry, 6, 435 (1967).

    Article  CAS  Google Scholar 

  22. Pruess, D. L., and Johnson, M. J., J. Bact., 94, 1502 (1967).

    CAS  PubMed  Google Scholar 

  23. Yoshida, T., Kumura, Y., and Katagiri, K., J. Antibiotics, 21, 465 (1968).

    Article  CAS  Google Scholar 

  24. Umezawa, H., Antibiotics Symp., Ste Margeurite, Quebec March 1971.

  25. Bullock, J. D., Adv. Appl. Microbiol., 3, 293 (1961).

    Article  Google Scholar 

  26. Woodruff, H. B., Sixteenth Symp. Soc. Gen. Microbiol., 22 (1966).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

DHAR, M., KHAN, A. Formation of Antibiotics. Nature 233, 182–184 (1971). https://doi.org/10.1038/233182a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/233182a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing