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Chromosomes of Cancer Cells

Nature volume 232, pages 632–633 (1971)Cite this article

Abstract

THE reported1 alterations in the malignant potential of a virus transformed mouse fibroblast cell line and its relationship to variations in the chromosome number seems to have a parallel in the human cervix. Our studies of the chromosome patterns seen in pre-invasive and invasive carcinomas of the uterine cervix suggest that these patterns may be an indicator of the invasive potential of the pre-invasive lesion2. We have proposed a theory in which we contend that the tetraploid and hypertetraploid pre-invasive lesions are less likely to develop into invasive carcinoma and that a potentially invasive lesion will have a peri-diploid component in its cytogenetic profile3.

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References

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, Queen Elizabeth Hospital, Woodville, South Australia

    J. A. KIRKLAND & M. A. STANLEY

Authors
  1. J. A. KIRKLAND
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  2. M. A. STANLEY
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KIRKLAND, J., STANLEY, M. Chromosomes of Cancer Cells. Nature 232, 632–633 (1971). https://doi.org/10.1038/232632a0

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