Abstract
IN a series of experiments designed to explore the cellular basis of immunological tolerance1, it was discovered that the response of the draining lymph nodes of mice to a subcutaneous injection of sheep red blood cells, was reduced by a slightly previous or simultaneous injection of the same antigen into the peritoneal cavity. This phenomenon will be termed “pre-emption”, in the sense that the intraperitoneal injection “appropriates or takes beforehand”2 the capacity to make a local immune response on subsequent subcutaneous injection. This is a descriptive term, pending the invention of a better one based on a clearly understood mechanism.
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References
Gershon, R. K., Wallis, V., Davies, A. J. S., and Leuchars, E., Nature, 218, 380 (1968).
Webster's New International Dictionary, 2nd ed. (1947).
Jerne, N. K., Nordin, A. A., and Henry, C., Cell Bound Antibodies (edit. by Amos, B., and Koprowski, H.), 109 (Wistar Institute Press, Philadelphia, 1963).
Dresser, D. W., and Wortis, H. H., Nature, 208, 859 (1965).
Wortis, H. H., Taylor, R. B., and Dresser, D. W., Immunology, 1, 603 (1966).
Adler, F. L., Prog. Allergy, 8, 41 (1964).
Radovich, J., and Talmage, D. W., Science, 158, 512 (1967).
Eidinger, D., Khan, S. A., and Millar, K. G., J. Exp. Med., 128, 1183 (1968).
Brody, N. I., and Siskind, G. W., J. Exp. Med., 130, 821 (1969).
Hunter, R. L., Millman, R. B., and Lerner, E. M., Transplantation, 8, 413 (1969).
Liacopoulos, P., Merchant, B., and Harrell, B. E., Transplantation, 5, 1423 (1967).
Dresser, D. W., Clin. Exp. Immunol., 3, 877 (1968).
Simic, M. M., and Petrovic, M. Z., Nature, 220, 1354 (1968).
Eidinger, D., and Pross, H. F., J. Exp. Med., 126, 15 (1967).
Finkelstein, M. S., and Uhr, J. W., Science, 146, 67 (1964).
Möller, G., and Wigzell, H., J. Exp. Med., 121, 969 (1965).
Uhr, J. W., and Möller, G., Adv. Immunol., 8, 81 (1968).
Rowley, D. A., Fitch, F. W., Axelrad, M. A., and Pierce, C. W., Immunology, 16, 549 (1969).
Henry, C., and Jerne, N. K., J. Exp. Med., 128, 133 (1968).
Halasz, N. A., Orloff, M. J., and Hirose, F., Transplantation, 2, 453 (1964).
Ockner, S. A., Guttmann, R. D., and Lindquist, R. R., Transplantation, 9, 39 (1970).
Ockner, S. A., Guttmann, R. D., and Lindquist, R. R., Transplantation, 9, 30 (1970).
Stewart, F. P., Saitoh, T., and Fitch, F. W., Science, 160, 1463 (1968).
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O'TOOLE, C., DAVIES, A. Pre-emption in Immunity. Nature 230, 187–189 (1971). https://doi.org/10.1038/230187a0
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DOI: https://doi.org/10.1038/230187a0
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