Abstract
THE role of vasoactive polypeptides as humoral mediators in acute pancreatitis has been the subject of much recent speculation. Both trypsin and kallikrein, normally present in the pancreas in an inactive form, are activated in acute pancreatitis, and these enzymes are able in turn to split the polypeptides bradykinin and kallidin from the alpha 2 globulins to which they are bound in the blood. The active peptides have well-known pharmacological properties which include pain production, increased capillary permeability, smooth muscle stimulation, production of hypotension and leucocyte aggregation. The severe pain, unique retroperitoneal oedema, hypotension, and shock encountered in acute pancreatitis suggest the presence of such a substance.
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NUGENT, F., ATENDIDO, W., BULAN, M. et al. Kininase Activity in Experimental Pancreatitis. Nature 211, 207–208 (1966). https://doi.org/10.1038/211207a0
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DOI: https://doi.org/10.1038/211207a0
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