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Determination of Nicotine in Smokers' Urine by Gas Chromatography

Nature volume 208, pages 788–789 (1965)Cite this article

Abstract

THE highly controversial subject of the effects of smoking on health has been extensively investigated and reviewed in recent years1,2. It has been reported that nicotine has an effect on the cardiovascular system. However, its relation to coronary disease is not fully understood. The absorption of nicotine as the result of smoking is dependent on a number of factors3. The quantitation of nicotine and its metabolites in the body fluids of smokers would be helpful for the investigation of the relation between nicotine exposure and heart disease. It should also give a more reliable estimate of the quantities of other tobacco smoke ingredients to which the body is exposed. This communication describes such a method.

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References

  1. Rep. to the Surgeon General of the U.S. Public Health Service Smoking and Health (1964).

  2. Little, C. C., Rep. of the Scientific Director, Council for Tobacco Research, U.S.A. (1964).

  3. Ref. 1, 74.

  4. Corcoran, A. C., Halmer, O. M., and Page, I., J. Biol. Chem., 128, 89 (1939).

    Google Scholar 

  5. Bowman, E. R., Turnbull, L. B., and McKennis, jun., H., J. Pharm. and Exp. Therapeutics, 127, 92 (1959).

    CAS  Google Scholar 

  6. Quin, L. D., J. Org. Chem., 24, 911 (1959).

    Article  CAS  Google Scholar 

  7. Quin, L. D., and Pappas, N. A., Agric. and Food Chem., 10, 79 (1962).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts

    NEAL L. MCNIVEN, KANAYA H. RAISINGHANI, SANFORD PATASHNIK & RALPH I. DORFMAN

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  1. NEAL L. MCNIVEN
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  2. KANAYA H. RAISINGHANI
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  3. SANFORD PATASHNIK
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  4. RALPH I. DORFMAN
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MCNIVEN, N., RAISINGHANI, K., PATASHNIK, S. et al. Determination of Nicotine in Smokers' Urine by Gas Chromatography. Nature 208, 788–789 (1965). https://doi.org/10.1038/208788a0

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  • DOI: https://doi.org/10.1038/208788a0

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