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Actively Acquired Tolerance to Tuberculo-Protein

Abstract

ANIMALS confronted in fœtal life, or shortly after birth, with antigenic substances may fail to develop an antibody response to such antigens in adult life. This inhibition of antibody response, termed ‘actively acquired tolerance’, is antigenically highly specific, and has been demonstrated with several unrelated antigens1.

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References

  1. Billingham, R. E., Brent, L., and Medawar, P. B., Phil. Trans. Roy. Soc., B, 239, 357 (1956).

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  2. Rich, A. R., “The Pathogenesis of Tuberculosis”, (2nd edit., Thomas, Springfield, Ill., 1951).

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WEISS, D., WELLS, A. Actively Acquired Tolerance to Tuberculo-Protein. Nature 179, 968–969 (1957). https://doi.org/10.1038/179968b0

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