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Complications after Transplant

Impact of circulating bone-resorbing cytokines on the subsequent bone loss following bone marrow transplantation

Bone Marrow Transplantation volume 34, pages 89–94 (2004)Cite this article

Summary:

Cytokines including IL-6 and TNF-α play an important role in the pathogenesis of postmenopausal osteoporosis. However, the relationship between changes in the cytokine levels and subsequent bone loss in patients undergoing a bone marrow transplantation (BMT) is unclear. A total of 46 patients undergoing an allogeneic BMT were prospectively investigated. The bone turnover markers and the serum cytokines were measured before BMT and serially after BMT. Bone mineral density (BMD) was measured before and 1 year after BMT. At 1 year after BMT, the lumbar spine BMD had decreased by 4.8%, and the total proximal femoral BMD had decreased by 12.3%. The serum IL-6 and TNF-α levels increased until 2 and 3 weeks after BMT, respectively. The lumbar BMD was significantly decreased as the serum IL-6 and TNF-α levels increased by post-BMT 3 weeks. The lumbar BMD decreased significantly as the cumulative prednisolone and cyclosporine dose increased. Patients with GVHD ⩾grade II had higher lumbar bone loss than patients with GVHD

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Acknowledgements

This study was supported by the Samsung grant (#SBRI C-A3-223-1) and the grant from the Korean Ministry of Health and Welfare (01-PJ1-PG1-01CH08-0001).

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Author notes

  1. W-Y Lee and K-H Baek: These authors contributed equally to the work reported and both should be considered as first authors

Authors and Affiliations

  1. Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

    W-Y Lee, E-J Rhee & S-W Kim

  2. Department of Internal Medicine, The Catholic University of Korea, College of Medicine, Seoul, Korea

    K-H Baek, H-J Tae, M-I Kang & K-W Lee

  3. Hallym University, College of Medicine, Chunchon, Korea

    K-W Oh

  4. Hematopoietic Stem Cell Transplantation Center, The Catholic University of Korea, College of Medicine, Seoul, Korea

    C-C Kim

  5. Department of Internal Medicine, Miz Medi Hospital, Seoul, Korea

    E-S Oh

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  1. W-Y Lee
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Correspondence to M-I Kang.

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Lee, WY., Baek, KH., Rhee, EJ. et al. Impact of circulating bone-resorbing cytokines on the subsequent bone loss following bone marrow transplantation. Bone Marrow Transplant 34, 89–94 (2004). https://doi.org/10.1038/sj.bmt.1704535

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  • DOI: https://doi.org/10.1038/sj.bmt.1704535

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