Abstract
THE preparation, and biological and preliminary chemical properties of trichothecin, an antifungal substance from Trichoihecium roseum Link, have been described1. From the data then available it was erroneously concluded that the compound was a lactone with the probable molecular formula C15H20O4. Further work has shown that trichothecin is an ester, C19H24O5, the components of which are isocrotonic acid and a ketonic alcohol, trichothecolone.
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References
Freeman, G. G., and Morrison, R. I., (a) Nature, 162, 30 (1948); (b) Biochem. J., 44, 1 (1949); (c) J. Gen. Microbiol., 3, 60 (1949).
Purdie, T., and Marshall, W., J. Chem. Soc., 59, 476 (1891).
Michael, A., and Schulthess, J., J. prakt. Chem. (2), 46, 236 (1892).
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FREEMAN, G., GILL, J. Alkaline Hydrolysis of Trichothecin. Nature 166, 698–699 (1950). https://doi.org/10.1038/166698b0
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DOI: https://doi.org/10.1038/166698b0
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