Abstract
PRIMETIN, C15H10O4, isolated from the leaves of Primula modesta1, has hitherto been regarded as 5:6-dihydroxyflavone (1), and several attempts have been made to prepare this compound2. An unambiguous synthesis of 5:6-dimethoxyflavone has now been carried out via the stages 2:6-dihydroxyacetophenone, 2-hydroxy-6-methoxyacetophenone, 2:5-dihydroxy-6-methoxyacetophenone, 2-hydroxy-5:6-dimethoxyacetophenone, 2-benzoyloxy-5:6-di-methoxyacetophenone, and 2-hydroxy-5:6-dimethoxydibenzoylmethane.
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References
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BAKER, W. Synthesis of 5: 6-Dihydroxyflavone and the Structure of Primetin. Nature 143, 900–901 (1939). https://doi.org/10.1038/143900b0
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DOI: https://doi.org/10.1038/143900b0
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