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Biological activities and molecular targets of the human papillomavirus E7 oncoprotein

Oncogene volume 20, pages 7888–7898 (2001)Cite this article

Abstract

The human papillomavirus (HPV) E7 protein is one of only two viral proteins that remain expressed in HPV-associated human cancers. HPV E7 proteins share structural and functional similarities with oncoproteins encoded by other small DNA tumor viruses such as adenovirus E1A and SV40 large tumor antigen. The HPV E7 protein plays an important role in the viral life cycle by subverting the tight link between cellular differentiation and proliferation in normal epithelium, thus allowing the virus to replicate in differentiating epithelial cells that would have normally withdrawn from the cell division cycle. The transforming activities of E7 largely reflect this important function.

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Acknowledgements

The work in the authors' laboratory is currently supported by Public Health Service grants R01 CA81135, R01 CA66980 and P01 DE12467 to K Münger. J Basile is supported by K16 DE00275, S Duensing by a fellowship from the Deutsche Forschungsgemeinschaft (Du 343/1-1) and A Eichten by a fellowship from the Deutscher Akademischer Austauschdienst. SL Gonzalez is a Ryan Fellow and is supported by a dissertation fellowship from the Ford Foundation. V Zacny is the recipient of a Senior Postdoctoral Fellowship from the New England Division of the American Cancer Society. K Münger gratefully acknowledges the valuable contributions of S Kcubrats and J Daniel to this article.

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    Karl Münger, John R Basile, Stefan Duensing, Alexandra Eichten, Sonia L Gonzalez, Miranda Grace & Valerie L Zacny

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Münger, K., Basile, J., Duensing, S. et al. Biological activities and molecular targets of the human papillomavirus E7 oncoprotein. Oncogene 20, 7888–7898 (2001). https://doi.org/10.1038/sj.onc.1204860

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