Featured
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News |
First US drug approved for a liver disease surging around the world
A therapy called resmetirom improves hallmarks of an obesity-linked condition that can lead to liver failure.
- Heidi Ledford
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Outlook |
Fungal diseases are spreading undetected
Low- and middle-income countries are grappling with widespread shortages of diagnostic tests for infections that kill millions.
- Charles Schmidt
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Nature Index |
Researchers call for a major rethink of how Alzheimer’s treatments are evaluated
An approach that aims to quantify how long a drug can delay or halt the progression of disease is gathering steam.
- Esther Landhuis
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News |
Ancient malaria genome from Roman skeleton hints at disease’s history
Genetic information from ancient remains is helping to reveal how malaria has moved and evolved alongside people.
- Tosin Thompson
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Research Briefing |
Dysregulated cellular stress management becomes a source of stress
Stress responses protect cells from harmful conditions, but once the stress has resolved, these responses must be actively turned off to avoid cell damage that might lead to the development of neurodegenerative disease.
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News |
Blockbuster obesity drug leads to better health in people with HIV
Semaglutide reduces weight and fat accumulation associated with the antiretroviral regimen that keeps HIV at bay.
- Mariana Lenharo
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News Explainer |
First cell therapy for solid tumours heads to the clinic: what it means for cancer treatment
Therapy built on tumour-infiltrating lymphocytes is now being prepared for at least 20 people in the United States with advanced melanoma.
- Sara Reardon
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Outlook |
Could the gut give rise to alcohol addiction?
Microorganisms in the gut might make a person more vulnerable to substance-use disorders.
- Tammy Worth
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Nature Podcast |
These tiny fish combine electric pulses to probe the environment
Elephantnose fish share electric pulses to extend their senses, and the bumblebees that show a uniquely human trait.
- Nick Petrić Howe
- & Benjamin Thompson
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Correspondence |
Personalized cancer care can’t rely on molecular testing alone
- James Larkin
- , Chloe Beland
- & Alexander R. Lyon
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Correspondence |
Forget lung, breast or prostate cancer? Why we shouldn’t abandon tumour names yet
- Albrecht Stenzinger
- & Frederick Klauschen
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News |
Meningitis could be behind ‘mystery illness’ reports in Nigeria
The WHO confirms three meningitis deaths, which it says might have triggered rumours of an outbreak of an unknown disease.
- Sarah Wild
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News |
Organoids grown from amniotic fluid could shed light on rare diseases
Organ-like groups of cells can be grown from amniotic fluid samples and offer hope for studying congenital conditions.
- Lilly Tozer
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News |
Brazil’s record dengue surge: why a vaccine campaign is unlikely to stop it
A vaccine shortage and persistent sanitation problems threaten the success of the world’s first public vaccination campaign against dengue virus.
- Mariana Lenharo
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News & Views |
Non-neuronal brain cells modulate behaviour
A single gene in astrocytes can constrain repetitive behaviours, indicating that these cells are regulators of behavioural disruption in conditions such as Huntington’s disease and obsessive–compulsive disorder.
- Anna Kruyer
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Spotlight |
Stealthy stem cells to treat disease
Gene-editing strategies that allow stem cells to evade the immune system offer hope for universal cell-replacement therapies.
- Elie Dolgin
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News & Views |
Synchronized neuronal activity drives waste fluid flow
Active neurons can stimulate the clearance of their own metabolic waste by driving changes to ion gradients in the surrounding fluid and by promoting the pulsation of nearby blood vessels.
- Lauren Hablitz
- & Maiken Nedergaard
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News Feature |
Can non-profits beat antibiotic resistance and soaring drug costs?
Effective, affordable antimicrobial drugs aren’t moneymakers, despite being desperately needed. Can non-profit organizations pick up the slack?
- Maryn McKenna
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News |
‘Epigenetic’ editing cuts cholesterol in mice
Changes to chemical tags on DNA in mice dial down the activity of a gene without cuts to the genome.
- Heidi Ledford
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Article
| Open AccessIncomplete transcripts dominate the Mycobacterium tuberculosis transcriptome
A study reveals that most transcripts in Mycobacterium tuberculosis are incomplete, likely because of the tendency of the transcription machinery in this species to pause on genomic DNA.
- Xiangwu Ju
- , Shuqi Li
- & Shixin Liu
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Article
| Open AccessCrym-positive striatal astrocytes gate perseverative behaviour
In mice, a population of astrocytes in the central striatum, characterized by expression of μ-crystallin, has a role in perseveration phenotypes that are often associated with human neuropsychiatric disorders.
- Matthias Ollivier
- , Joselyn S. Soto
- & Baljit S. Khakh
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Correspondence |
Speed up relief for long COVID through grassroots clinical trials
- Marc Jamoulle
- , Elena Louazon
- & Johan Van Weyenbergh
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Nature Podcast |
Audio long read: Chimpanzees are dying from our colds — these scientists are trying to save them
Endangered apes are increasingly being put at risk by human diseases.
- Rachel Nuwer
- & Benjamin Thompson
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News |
The surprising link between gut bacteria and devastating eye diseases
Finding raises hopes that antibiotics could treat some genetic diseases that can cause blindness — but also prompts doubts.
- Saima Sidik
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Comment |
Save lives in the next pandemic: ensure vaccine equity now
The proposed Pandemic Agreement must ensure that COVID-19 vaccine nationalism is never repeated; 290 scientists call for action.
- Colin Carlson
- , Daniel Becker
- & Alexandra Phelan
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News |
CAR-T therapy for multiple sclerosis enters US trials for first time
Hopes are high that engineered immune cells, which are already in use to treat blood cancer, will halt the progression of a degenerative autoimmune disorder.
- Asher Mullard
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News |
Drug-resistant microbes: ‘brain drain’ is derailing the fight to stop them
A lack of investment is driving researchers who study antimicrobial resistance out of the field, an industry body warns.
- Lilly Tozer
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Article
| Open AccessPrevalence of persistent SARS-CoV-2 in a large community surveillance study
Using viral sequence data, individuals with persistent SARS-CoV-2 infections were identified, and had higher odds of self-reporting long COVID, in a large community surveillance study.
- Mahan Ghafari
- , Matthew Hall
- & Katrina Lythgoe
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Research Highlight |
Just a few counselling sessions can hold postpartum depression at bay
Even talking to a non-specialist during pregnancy was enough to reduce the risk of depression and anxiety after birth.
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News |
Ambitious survey of human diversity yields millions of undiscovered genetic variants
Analysis of the ‘All of Us’ genomic data set begins to tackle inequities in genetics research.
- Max Kozlov
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Article
| Open AccessGenetic drivers of heterogeneity in type 2 diabetes pathophysiology
A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.
- Ken Suzuki
- , Konstantinos Hatzikotoulas
- & Eleftheria Zeggini
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News |
Move over, CRISPR: RNA-editing therapies pick up steam
Two RNA-editing therapies for genetic diseases have in the past few months gained approval for clinical trials, raising hopes for safer treatments.
- Mariana Lenharo
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News |
Smoking scars the immune system for years after quitting
A cigarette habit and previous infection with a common virus both have important effects on the immune system.
- Heidi Ledford
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Article |
Deep whole-genome analysis of 494 hepatocellular carcinomas
The Chinese Liver Cancer Atlas project depicts a panoramic genomic landscape of hepatocellular carcinoma, covering candidate coding and non-coding drivers, mutational signatures, extrachromosomal circular DNA, subclonal catastrophic events and detailed evolutionary history.
- Lei Chen
- , Chong Zhang
- & Hongyang Wang
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News |
Early dementia diagnosis: blood proteins reveal at-risk people
The results of a large-scale screening study could be used to develop blood tests to diagnose diseases such as Alzheimer’s before symptoms take hold.
- Miryam Naddaf
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Article
| Open AccessCirculating myeloid-derived MMP8 in stress susceptibility and depression
Serum MMP8 is increased in stress-susceptible mice following chronic stress and leads to brain structure and behavioural changes in mice.
- Flurin Cathomas
- , Hsiao-Yun Lin
- & Scott J. Russo
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Article |
Convergence of coronary artery disease genes onto endothelial cell programs
Variant-to-gene-to-program is a new approach to building maps of genome function to link risk variants to disease genes and to convergent signalling pathways in an unbiased manner; its strength is demonstrated in coronary artery disease.
- Gavin R. Schnitzler
- , Helen Kang
- & Jesse M. Engreitz
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Comment |
No ‘easy’ weight loss: don’t overlook the social cost of anti-obesity drugs
Ideas of diet and exercise as the ‘best’ way to lose weight could stigmatize people taking Ozempic, WeGovy and other blockbuster drugs that affect appetite. Lessons from weight-loss surgery reveal ways to help.
- Alexandra Brewis
- & Sarah Trainer
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Article
| Open AccessMatrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver
Structural changes mediated by advanced glycation end-products enhance extracellular matrix viscoelasticity, and that viscoelasticity can promote cancer progression in vivo, independent of stiffness.
- Weiguo Fan
- , Kolade Adebowale
- & Natalie J. Török
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News |
Signs of ‘transmissible’ Alzheimer’s seen in people who received growth hormone
The findings support a controversial hypothesis that proteins related to the neurodegenerative disease can be ‘seeded’ in the brain through material taken from cadavers.
- Carissa Wong
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Nature Podcast |
Audio long read: Long COVID is a double curse in low-income nations — here’s why
A dearth of research means the condition is often ignored by physicians.
- Heidi Ledford
- & Benjamin Thompson
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News |
Obesity drugs have another superpower: taming inflammation
The blockbuster medications that reduce body weight also reduce inflammation in organs such as the brain, raising hopes that they can treat Parkinson's and Alzheimer's diseases.
- Mariana Lenharo
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Outlook |
Tracking down tuberculosis
Improvements in screening and diagnosis could help to eradicate this curable disease.
- Neil Savage
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Article
| Open AccessRedefining the treponemal history through pre-Columbian genomes from Brazil
Reconstruction of four Treponema pallidum genomes associated with human remains from around 2,000 years ago suggests that T. pallidum existed in the Americas and diverged to its modern subspecies before the fifteenth century European contact with the Americas.
- Kerttu Majander
- , Marta Pla-Díaz
- & Verena J. Schuenemann
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Article
| Open AccessThe HIV capsid mimics karyopherin engagement of FG-nucleoporins
Dissection of the nuclear pore complex provides a model in which the HIV capsid enters the nucleus through karyopherin mimicry, a mechanism likely to be conserved across other viruses.
- C. F. Dickson
- , S. Hertel
- & D. A. Jacques
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Article
| Open AccessDeciphering cell states and genealogies of human haematopoiesis
An improved, single-cell lineage-tracing system, based on deep detection of naturally occurring mitochondrial DNA mutations with simultaneous readout of transcriptional states and chromatin accessibility, is used to define the clonal architecture of haematopoietic stem cells.
- Chen Weng
- , Fulong Yu
- & Vijay G. Sankaran
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Article
| Open AccessAutoreactive T cells target peripheral nerves in Guillain–Barré syndrome
Autoreactive T cells that target myelin antigens in the peripheral nerves are present in patients with the demyelinating form of Guillain–Barré syndrome, and these T cells are likely to contribute to disease pathophysiology.
- L. Súkeníková
- , A. Mallone
- & D. Latorre
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News Feature |
Chimpanzees are dying from our colds — these scientists are trying to save them
Humans are increasingly passing pathogens to animal populations, imperilling endangered species such as chimpanzees and gorillas.
- Rachel Nuwer
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